The composition of the drug is as follows:

  • active component - ursodeoxycholic acid;
  • additional components - corn starch, silicon dioxide colloidal, gelatin, magnesium stearate, titanium dioxide.

Release form

Ursosan is sold in white hard capsules. Inside the capsules is white powder.

Pharmachologic effect

The drug is hepatoprotectiveIt also works as choleretic, lipid-lowering, immunomodulatory, cholelitholytic and hypocholesterolemic means.

Pharmacodynamics and pharmacokinetics

The composition determines the effect of this drug. Its active component is ursodeoxycholic acid. Wikipedia and many other sites call this drug exactly that. Ursodeoxycholic acid has high polar properties and creates non-toxic mixed micelles with toxic bile acids. This causes the ability to decrease. gastric reflux damage cell membranes when they appear reflux esophagitis and biliary reflux gastritis. In addition, the drug Ursosan creates double molecules entering the cell membranes hepatocytes, epithelial cells Gastrointestinal tract cholangiocytes. These molecules stabilize them and make them immune to the effects. cytotoxic micelles.

The active substance of the drug also reduces the content of bile acids, which are toxic to hepatocytes, and stimulates choleresissaturated with bicarbonates. Thanks to this, it disappears intrahepatic cholestasis. Ursodeoxycholic acid reduces lithogenic index bile and concentration cholesterol by inhibiting its absorption in the intestine, reducing secretion in bile, inhibiting synthesis in the liver. Eventually dissolve cholesterol gallstones. The tool also prevents the emergence of new calculi.

The drug acts as immunomodulatory expression inhibition agent HLA-2 antigens and HLA-1 and normal improvements killer activity lymphocytes. In addition, it impedes development. fibrosis in people with primary biliary cirrhosisas well as alcoholic steatohepatitis and cystic fibrosis. Reduces the chance of occurrence varicose veins in the esophagus, slows premature aging and cell death.

The active substance of the drug is absorbed from the small intestine through passive diffusion (degree absorption approximately 90%), and in the ileum due to active transport. The maximum concentration is reached after about 60-180 minutes.

The degree of communication with plasma proteins is up to 99%. With constant use ursodeoxycholic acid becomes the main bile acid in the blood serum. The therapeutic effect of the drug depends on its content in bile.

The drug breaks down in the liver with the formation of such products metabolism, as glycine and taurine conjugate. They are secreted in bile. Approximately 60% of the total dosage is excreted in the bile. A certain amount of the active substance is also transported to the colon, where it is broken down by bacteria. Lithocholic acid slightly absorbed from the colon sulfates in the liver and is excreted as sulfolithocholylglycine or sulfolithocholyl taurine conjugate.

Indications Ursosan

The forums are often interested in why pills can help in a particular case. Experts do not recommend taking them without consulting a doctor. Only he can determine if there are indications for the use of Ursosan. In addition, he selects the desired treatment regimen.

If you have been prescribed Ursosan tablets, indications for use are usually as follows:

  • uncomplicated cholelithiasis;
  • the need to prevent relapse of stone formation after cholecystectomy;
  • acute hepatitis;
  • alcoholic disease and primary biliary cirrhosis;
  • dyskinesia bile ducts;
  • cystic fibrosis of the liver;
  • biliary dyspeptic syndrome;
  • toxic liver damage;
  • chronic active hepatitis;
  • non-alcoholic steatohepatitis;
  • atresia intrahepatic biliary tract;
  • primary sclerosing cholangitis;
  • biliary reflux gastritis and reflux esophagitis;
  • the need to prevent liver damage when taking hormonal contraceptives and cytostatics.


This drug cannot be used with hypersensitivity to its components, non-functioning gallbladder, chronic hepatitis, pancreatitisacute cholecystitis, cirrhosis of the liver (with decompensation)acute cholangitisacute infectious diseases of the gallbladder, diseases of the bile duct, of pregnancy, breastfeeding, bile gastrointestinal fistula, gallstones with a high content of Ca2 +, inflammatory diseases of the small and large intestine, liver failure, renal failure, empyema gallbladder, obturation biliary tract.

Side effects of Ursosan

Reviews of side effects appear infrequently. However, if any adverse reactions occur, you should definitely consult a doctor.

The following side effects of Ursosan are known:

  • vomiting
  • aggravation psoriasis;
  • nausea;
  • diarrhea;
  • transient increase in hepatic activity transaminase;
  • constipation;
  • pain in the back;
  • allergy;
  • alopecia.

In rare cases, it is possible calcination gallstones.

Instructions for use Ursosan (Method and dosage)

For those who have been prescribed Ursosan tablets, the instructions for use report that they need to be taken orallywhile washing down with liquid.

The medicine has different dosage regimens depending on the disease. For those who are interested in how to take Ursosan: before meals or after - it is also reported that this is individual, depending on the indications for use.

When diffuse liver disease and gallstone disease the course of treatment can last from several months to several years, the daily dosage is usually 10-15 mg per 1 kg of patient body weight (2-5 capsules). At gallstone disease daily dosage is taken once immediately before bedtime. The treatment is carried out until the stones dissolve, and then another 3 months so that the stones do not form again. At diffuse liver disease instructions for use Ursosan reports that the daily dosage should be divided into 2-3 doses. The tool must be taken with meals.

After cholecystectomy and to prevent re cholelithiasisAs a rule, 250 mg 2 times a day are prescribed. The course is designed for several months.

At primary biliary cirrhosis the medicine is taken in a dosage of 10-15 mg per 1 kg of patient body weight per day. If necessary, it can be increased to 20 mg per 1 kg. The dosage should be divided into 2-3 doses. The course of treatment lasts from 6 months to several years.

If the patient non-alcoholic steatohepatitis, take 13-15 mg per 1 kg of patient weight per day. The dosage should be divided into 2-3 doses. The course of treatment can last from 6 months to several years.

When biliary reflux gastritis and reflux esophagitis the medicine is taken 1 capsule (250 mg) per day immediately before bedtime. Therapy is carried out from 10 days to 6 months. If necessary, it can be extended up to 2 years.

At liver lesions, atresia biliary tract and alcoholic liver disease the daily dosage is usually 10-15 mg per 1 kg of patient weight. The daily dosage should be divided into 2-3 doses. The course is designed for six months, a year or more.

If the patient has primary sclerosing cholangitis, the doctor prescribes, as a rule, 12-15 mg per 1 kg of patient weight per day. If necessary, the dosage can be increased to 20 mg per 1 kg of weight. The total daily dose is divided by the patient into 2-3 doses. The course of admission is from six months to several years.

At cystic fibrosis the drug is taken in dosages of 20-30 mg per kg per day. The dose should be divided into 2-3 doses. The course lasts from six months to several years.

For children from 2 years of age, the amount of the drug taken per day is set individually by a specialist. Usually prescribed 10-20 mg per kg per day.

In order to eliminate the expressed and dangerous jaundice in some cases, specialists prescribe this tool for newborns. Therapy is designed for 2-4 weeks. Instructions for use of Ursosan for newborns reports that the dosage for children of this age is a quarter of a capsule every day. The powder in it spills out on a saucer. Then it is divided into four equal parts, one of which is given to the baby. It must first be dissolved in water or breast milk. If the treatment is successful, the course can be reduced to 10 days. At the same time, you need to monitor the content bilirubin in blood. On average, during the week its level decreases by 50 units. After the concentration in the blood becomes 100 mg / ml, the medicine can be canceled.


An overdose of this drug was not reported.


Antacids with Al3 + and ion exchange resins able to reduce the degree of absorption of the drug. Hypolipidemic drugs estrogens, as well as Neomycin or progestins level up cholesterol in bile and reduce the degree of dissolution cholesterol bile calculi.

Terms of sale

This medicine is only available on prescription.

Storage conditions

Keep the capsules in a dry place inaccessible to children and well protected from the penetration of sunlight. The optimum temperature regime is up to 25 ° C.

Shelf life

Four years.

Ursosan analogs

Matches for ATX Level 4 code:UrsodexHenofalkUrsolivUrsofalkHoludexanUrsocholUrsodezUrdoxLivodex

The name of the analogues of this drug is presented in the following list:

  • Ursolak;
  • Ursoliv;
  • Ursolysin;
  • Ursomax;
  • Ursonost;
  • Ursofalk;
  • Ursochol;
  • Essentiale;
  • Holudexan.

All analogues of Ursosan have their own characteristics of action and application. None of them can be replaced independently without consulting a doctor. The price of analogues can be different depending on the amount of medicine in one package. However, in most cases, their cost is higher than the described drug in a similar amount.

Let's consider some analogues of Ursosan in more detail.

Ursofalk or Ursosan - which is better?

In most cases, experts consider when choosing between these two drugs that the first remedy is better. This is confirmed by many clinical observations, patient reviews and many years of practice. People who took both drugs note that Ursofalk easier to carry. And experts report that it dissolves gallstones faster and improves the condition of the liver. However what is the difference Ursosana and Ursofalka for each specific case, can only be understood in practice. There are people for whom a medicine like Ursosan is more suitable. So you can set a course first Ursofalka, and if the treatment has not been effective enough, go to another drug. Thus, you can choose the best method of therapy.

Ursosan or Essentiale - which is better?

As a hepatoprotector Essentiale It is much more effective for maintaining liver function. In addition, this tool does not have so many side effects. So for those who choose a drug if it is necessary to normalize liver function, doctors in most cases recommend a second remedy. Ursosan is more expensive and has less effect on the cellular structure.

Urdoxa or Ursosan - which is better?

Urdox - a domestic product, which is generic Ursosana. However, all the necessary components for its manufacture are purchased abroad. Thus, all the components in it are the same as in the original preparation. So the answer to the question: "Urdox or Ursosan - which is better? "- does not exist. In fact, these are complete analogues, and the difference between them lies only in the manufacturing country. Many, however, choose a domestic product, since its cost is much less.

Ursoliv or Ursosan - which is better?

Both drugs have the same main component. Some patients tolerate one drug better, and some others. In this situation, individual effectiveness can only be tested in practice. All this depends on the characteristics of the body, so you should start taking one of the drugs, and if it does not help, go to another. Objective signs that help determine the effectiveness of each of these drugs do not exist. Many patients prefer to try each of the drugs, and then choose the most effective.

Ursosan for newborns

Reviews about this drug indicate that it is effective for newborns, if appropriate, is available. At high concentration bilirubin in babies blood may develop a physiological jaundice.

Ursosan in this case has its own established application scheme.

With alcohol

Since the drug among the indications has alcoholic liver damage, it was tested for compatibility with alcohol. After all, it is difficult for people taking this drug to abandon the addiction, even if it has already affected the body in an unfavorable way. As a result of studies, it was found that the drug does not lose its effectiveness when drinking alcoholic beverages. This is confirmed by the improvement of blood biochemical parameters in people with this dependence.

Ursosan during pregnancy (and lactation)

At of pregnancy this drug is recommended to be taken only if the intended benefit for the woman exceeds the possible risk to the child.

During breastfeeding it is not advisable to use this drug, since there is no data on the interaction of its active substance with breast milk.

Reviews about Ursosan

Reviews about the treatment with the drug can often be found in specialized forums. In particular, doctors express their opinion. They note the effectiveness of this drug. Patient reviews are also mostly positive. Some take it as a prophylactic in cases when a large load on the liver is expected.

Regarding the use for newborns, doctors' reviews about Ursosan, as a rule, report that the treatment was effective. Parents turn to them when they appear in children jaundice. Those who gave the medicine according to the prescription of a specialist leave reviews about Ursosan, which say that the drug helped.

Ursosan price, where to buy

This drug can be bought in Ukraine, Belarus and Russia. How much this drug costs depends largely on the number of capsules in one package. The average price of Ursosan in Ukraine:

  • capsules of 50 pieces per pack - 370 hryvnia;
  • capsules of 100 pieces per pack - 640 hryvnias;
  • capsules of 10 pieces per pack - 70 hryvnia.

The cost of the drug in Minsk and other cities of Belarus:

  • capsules of 50 pieces per pack - approximately 300 thousand Belarusian rubles;
  • capsules of 10 pieces per pack - approximately 70 thousand Belarusian rubles.

You can buy this tool in Moscow and other cities of Russia at the following prices:

  • Ursosan price 100 tablets (250 mg) - about 1400 rubles;
  • the price of Ursosan 50 capsules - about 770 rubles;
  • the price of packaging for 10 capsules is about 180 rubles.
  • Online Pharmacies in Russia
  • Online pharmacies in UkraineUkraine
  • Online pharmacies in Kazakhstan


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  • Ursosan 250 mg No. 10 caps.PRO.MED.CS Praha a.s. (Czech Republic) 1 tenge
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Watch the video: Урсосан инструкция по применению, отзывы. (January 2020).

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