The composition of the drug Pentamine contains 50 mg of active substance azamethonium bromide (INN funds) per 1 ml + excipients.

Release form

The medicine is released in the form of a clear solution for infusion, in ampoules of 1 or 2 ml. Ampoules in cardboard boxes of 5 or 10 pieces each.

Pharmachologic effect

Ganglion blocking, antispasmodic.

Pharmacodynamics and pharmacokinetics

The active substance of the drug Pentamine blocks n-cholinergic receptors sympatheticand parasympathetic vegetative ganglia. Thus, the drug inhibits activity carotid glomeruliand adrenal chromaffin tissue.

The medicine has the ability to reduce arterial pressurerenders arterodilating and venodilating effect.

Withdrawal Intensity catecholamines adrenal gland decreases, weakening occurs reflex pressor reactions.

Thus, the medicine causes tachycardia, mydriasis, expansion of the bronchi, reduces motility Gastrointestinal tract, secretory activity of various glands, bladder tone.

Indications for use

The drug is prescribed:

  • at hypertension first and second stages;
  • for stopping hypertensive crisis;
  • at spasms of blood vessels on the periphery, gall bladder, intestines;
  • as part of a comprehensive treatment for pulmonary edema or cerebral edema;
  • at renal colic;
  • during cytoscopy in men;
  • at bronchial asthma;
  • to create a manageable hypotension during operations.


Injections are contraindicated:

  • at angle-closure glaucoma;
  • during the acute phase myocardial infarction;
  • sick thrombophlebitis;
  • with severe arterial hypotension;
  • if the patient is in a state shock;
  • with diseases of the liver or kidneys;
  • at allergies on any of the components of the product;
  • sick pheochromocytoma;
  • with degenerative diseases of the nervous system.

Side effects

During the use of Pentamine, the following were observed:

  • heart rate weakness, dizziness, palpitations;
  • orthostatic collapsedilated pupils, dry mucous membranes;
  • atony bladder or intestines, anuria;
  • scleral vascular injection.

Instructions for use of Pentamine (method and dosage)

The drug is administered intramuscularly or intravenously depending on indications.

Dosage and administration are usually determined by the doctor.

Pentamine instructions for use

Injection should be done slowly, controlling HELL and general well-being of the patient.

At spasms of blood vessels injected IM up to 2 ml of the drug 2-3 times a day.

At pulmonary edema, brain, hypertensive crisis - up to 0.5 ml intravenously or drip (in solution glucose or sodium chloride).

If you need to administer medication to the patient to create a controlled hypotensionduring the operation, 0.8-1.2 ml of solution is used. If necessary, you can enter an additional 2.4-3.6 ml of the substance.

The maximum single dose is 3 ml. A patient is allowed to give no more than 9 ml of the drug per day.


An overdose may occur. orthostatic collapse, increased incidence of adverse reactions, a strong decrease HELL, the patient may stop breathing.

As therapy, it is shown to give the victim a position with raised legs, enter anticholinesterase drugs, alpha adrenomimetics, m-cholinomimetics, produce if necessary mechanical ventilation.


When combined with pentamine adrenomimetics the effect of the latter is greatly enhanced, dosage adjustment is required.

Use with caution ganglion blockers from tricyclic antidepressants.

Anticholinesterase drugs neutralize the effect of the drug.

Terms of sale

To get the medicine, you need a prescription.

Storage conditions

Keep ampoules in a dark, cool place to which children do not have access.

Shelf life

5 years.

Special instructions

Treatment should be carried out under the supervision of a specialist.

In patients open angle glaucoma with therapy, the drug may increase intraocular pressure.

During the injection and within 2 hours after the patient should be in a horizontal position.

Before treatment, it is recommended to test the introduction of the drug, half of the estimated dose, after a while you can enter the remaining amount of the drug.

If the patient has been elevated before taking the medicine arterial pressure, it must be borne in mind that it will decline sharply.


Matches for ATX Level 4 code:Benzohexonium

Pendiomide, Azamethonium Bromide, Pentamethasene.


There are very few reviews about the drug Pentamine. Of those that are, mostly good. The medicine, as a rule, is used in a hospital and under the supervision of a doctor, so the likelihood of developing adverse reactions is minimal.


If you have a prescription, you can buy the medicine in almost any pharmacy. Its cost is about 780 rubles per 10 ampoules.

Watch the video: My friends Pentamine (January 2020).

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