In 1 tablet tamoxifen citrate 10 or 20 mg.

Release form

Coated tablets of 10 and 20 mg.

Pharmachologic effect

Antiestrogen(prevents the formation of female sex hormones) antitumor.

Pharmacodynamics and pharmacokinetics


Nolvadex - non-steroid estrogen antagonist. Specifically binds to estrogen receptors in peripheral and tumor tissues. Thus, it eliminates the influence of estrogens produced in the body and stimulating the growth of cancer cells.

Slows the progression of the tumor process. After taking a single dose for several weeks, the ability to block estrogens will remain. Causes ovulation in women, in men with oligospermiaincreases the level of LH and FSH.


When taken orally, it is rapidly absorbed, and after 5-7 hours, the maximum concentration is created in the blood. 99% bound to blood proteins (albumin) Excretion occurs in two phases: the initial T 1/2 from 8 to 14 hours, the final T 1/2 - 7 days. It is excreted in feces, only a small part with urine.

Indications for use

Nolvadex is used for:

  • estrogen-dependent breast tumors in women during postmenopausal women;
  • endometrial cancer.


Nolvadex tablets are contraindicated in:

  • hypersensitivity;
  • pregnancy
  • breastfeeding;
  • cataract;
  • pronounced thrombophlebitis;
  • leukopenia, thrombocytopenia.

Side effects

Nolvadex may cause the following adverse reactions:

  • dizziness;
  • gastrointestinal upsets and nausea;
  • uterine bleeding, endometrial hyperplasia, uterine fibromaitching of the vulva;
  • fluid retention in the body;
  • hypercalcemia;
  • thrombocytopenia, leukopenia;
  • alopecia;
  • bone pain
  • changes in the retina;
  • thromboembolism.

Instructions for use (Method and dosage)

Nolvadex tablets are taken orally without chewing, washed down with water. It is possible to take the entire dose at once in the morning or in two doses - in the morning and in the evening. At breast cancer 20-40 mg are prescribed, with endometrial cancer - 30-40 mg. The maximum diabetes is 40 mg. The treatment is carried out for a long time, often in combination with cytostaticand radiation therapy.

During the treatment period, blood coagulation, leukocytes, platelets, blood calcium level, and liver function are controlled. An ophthalmologist is examined quarterly and a gynecological examination is performed. The drug Nolvadex is ineffective in the presence of metastases(especially in the liver).


It is manifested by an increase in side effects. Symptomatic treatment is carried out. The antidote does not exist.


Nolvadex (Tamoxifen) enhances the effect anticoagulants. Concomitant use of the drug with estrogen-containing contraceptives causes a decrease in the action of both drugs.

Application with Tegafurcan lead to hepatitisand cirrhosis. Allopurinolalso enhances its hepatotoxic effect.

Joint reception with cytostaticssignificantly increases the risk of thrombosis.
Reception with thiazide diuretics increases the risk of hypercalcemia.

H2-histamine receptor blockers and antacidsmay cause premature dissolution of enteric tablets, so the time between taking these drugs should be 2 hours.

Terms of sale

Nolvadex tablets are a prescription.

Storage conditions

At a temperature up to 30C.

Shelf life

5 years.


Matches for ATX Level 4 code:TamoxifenFarestonVero-Tamoxifen

Vero-TamoxifenTamifenTamoxifen, Tamoxifen Hexal, Zitazonium, Tamaxin, TamofenTamoxifer citrate, Tamoplex, Valodex, Cytofen, Noltam, Zemid.


Despite the fact that Tamoxifen is used to treat and prevent relapse breast cancer since 1998, it can now be considered the "gold standard" in the treatment of this disease. Nolvadex or its substitutes are used today in oncology, which is confirmed by the reviews of patients who are prescribed this drug for a long time.

"The right breast was removed, after a course of radiation therapy, Tamoxifen was prescribed for 5 years."

It was proved that the effectiveness of the drug increases with prolonged use and it began to be prescribed immediately for five years of continuous use. This reduces the mortality of patients after discontinuation and prolongs life for decades. Treatment estrogen antagonists prevents the possibility tumor metastasis. After this period, the oncologist assesses the condition and draws conclusions: prolong the treatment, add cytotoxic drugs or aromatase inhibitors.

According to some reports, the drug is effective only in older women. After prolonged use of the drug, adverse reactions are reported, which patients report: pain in the hip joints, weight gain, hair loss, phlebeurysm and thrombophlebitisitching.

The drug can be prescribed with preventive purposeto prevent breast cancer in women who are predisposed to this disease. Concrete data were obtained that taking the drug reduces the risk of developing breast cancer by a third. However, an unexpected side effect was detected - there is a risk of uterine sarcomas. Discussions are ongoing and clinical trials are ongoing. When prescribing Tamoxifen for prevention, the doctor should discuss with the patient the benefits of the drug and the existing risk.

Price, where to buy

At the moment, it is impossible to purchase Nolvadex in pharmacies in Moscow and other cities of Russia due to the expiration of the registration period for the drug.

In pharmacies, Vero-Tamoxifen 20 mg No. 30 for the price of 107-126 rubles, Tamoxifen Hexal 10 mg No. 30 for the price of 99-114 rubles, and Tamoxifen Ebeve are offered.

  • Online Pharmacies in Russia

LuxPharma * special offer

  • Nolvadex (Nolvadex) tab. 20mg №201800 rub.order
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Watch the video: Nolvadex Tamoxifen Facts: By Dylan Gemelli (January 2020).

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