One tablet contains 1.321 milligrams prucaloprida succinatethat corresponds to 1 milligram prucaloprida. The core of the tablet contains from 1 to 6 milligrams of film coating, 1.35 milligrams of magnesium stearate, 0.36 milligrams of colloidal silicon dioxide, 27 milligrams of microcrystalline cellulose and 149.969 milligrams of lactose monohydrate. The 40 percent film coating consists of 6 cP hypromellose, 24 percent titanium dioxide, 8 percent macrogol 3000, 6 percent tiracetin, and 22 percent lactose monohydrate.

Pink tablets contain 2 milligrams of prucaloprid, and the film coating additionally contains 0.02 percent indigo carmine (E132) and 0.01 percent yellow iron oxide dye (E172).

Release form

Available in the form of white or pink round biconvex tablets, which are engraved on one side with "PRU 1" or "PRU 2".

Pharmachologic effect

Resolor is a stimulant of serotonin receptors. The active substance contained in the tablets of this drug is dihydrobenzofurancarboxamide, which enhances intestinal motility. This is a selective, high-affinity agonist of 5HT-serotonin receptors, which explains its effect on intestinal motility.

Pharmacodynamics and pharmacokinetics

Prucaloprid is rapidly absorbed and after a single oral dose of two milligrams, the maximum concentration is reached after 2-3 hours. Absolute bioavailability is more than 90 percent, and eating does not affect bioavailability.

After ingestion, prucaloprid is distributed throughout the body and binds to plasma proteins by 30 percent.

In vitro metabolism in the human liver is very slow, resulting in very few metabolites. It is excreted unchanged - 60 percent is excreted through the kidneys and 6 percent with feces.

Indications for use

Used in symptomatic therapy chronic constipation in women, in cases where laxatives can not provide the desired effect to eliminate the symptoms.


Resolor can not be taken with:

  • congenital lactase deficiencyglucose-galactose malabsorption, lactose intolerance;
  • mechanical bowel obstruction, obstruction or perforation of the intestine due to functional or anatomical disorders of the intestinal wall, severe intestinal inflammation, for example, toxic megacolon / megarectum, Crohn's disease;
  • impaired renal function, which require dialysis;
  • hypersensitivity to prucaloprid or other substances in the composition of the drug.

Caution should be taken in the presence of severe and clinically unstable concomitant diseases of the lungs, liver, neurological, cardiovascular, mental, oncological, endocrine, and Aids.

Side effects

The most common adverse effects when taking this drug are headacheand adverse reactions of the gastrointestinal tract in the form of diarrhea, nausea and stomach pains. These effects were observed in 20 percent of patients who took the drug. As a rule, such reactions develop at the beginning of treatment and pass after a few days, so they do not require discontinuation of the drug. Other side effects are observed sporadically and have a mild or moderate severity. These include:

  • feeling unwell, fever, weakness;
  • pollakiuria;
  • anorexiapathological intestinal murmurs, flatulence, rectal bleeding, dyspepsia, vomiting;
  • heartbeat;
  • tremor, dizziness.

Instructions for use Resolor (Method and dosage)

The instructions on Resolor indicate that tablets should be taken orally at any time of the day, regardless of the meal. Adults are recommended to take 2 milligrams once a day, for older people (over 65 years old), start by taking 1 milligram once a day and, if necessary, increase the dose to 2 milligrams once a day. For children and adolescents under 18 years of age, the drug is not recommended.

For patients with severe hepatic impairment (Child-Pugh class C), 1 milligram can be taken once a day. Those who have mild or moderate hepatic impairment do not need to adjust the dose. People with severe renal impairment can take 1 milligram once a day. Having weak or slightly pronounced renal dysfunction, dose adjustment is unnecessary.

If taking the drug once a day for four weeks does not give a result, it is necessary to re-examine the patient and determine the feasibility of further use of the drug.


According to studies involving healthy people, the active substance of the tablets has good tolerance when increasing the dose to 20 milligrams once a day. In case of an overdose, symptoms may occur that are caused by increased side effects of the drug, including diarrhea, nausea, and headache.

There is no specific antidote. In case of an overdose, if necessary, symptomatic and supportive therapy is carried out. With a large loss of fluid due to vomiting or diarrhea, it is necessary to correct electrolyte imbalance.


The drug has a weak ability to interact, but it can weakly bind to P-glycoprotein. Prukaloprid also has no significant effect on pharmacokinetics. paroxetine, ethyl alcohol, Digoxin and Warfarin.

Approximately 40 percent increase in AUC of prucaloprid Ketoconazole at a dose of 200 milligrams twice a day, but this effect is very small to be of clinical significance. The same interaction is observed with Quinidine, Cyclosporin A and Verapamil.

Atropine-like substances can attenuate the effect of prukaloprid, and it should also be carefully taken simultaneously with drugs that can lengthen the QTc interval.

Terms of sale

Available from pharmacies with a prescription.

Storage conditions

Tablets should be stored in the original packaging in order to protect against moisture at an air temperature of no higher than 25 degrees.

Shelf life

The shelf life of the tablets is three years.

Analogs of Resolor

Matches for ATX Level 4 code:RamnilBuckthorn barkLavacol

The analogue of Resolor is Prukaloprid (Prucalopride).

Resolor Reviews

According to reviews of Resolor, side effects in the form of headaches, diarrhea, nausea and vomiting are observed quite often, but the drug is very effective.

Resolor price where to buy

You can buy Resolor in Moscow pharmacies from 1,500 rubles (1 milligram of active substance in a tablet) to 2,000 rubles (2 milligrams of active substance in a tablet).

  • Online Pharmacies in Russia


  • Resolor tab. p.p.o. 1mg n28Janssen-Cilag S.p.A1377 rub.order
  • Resolor tab. p.p.o. 2mg n28Janssen-Cilag S.p.A. 2005 rub.order

Pharmacy Dialog

  • Resolor (tab.2mg No. 28) 2149 rub.order
  • Resolor (tab. 1mg No. 28) 1505 rub.order

Eurofarm * 4% discount on the promotional code medside11

  • Resolor 2 mg 28 tablets Janssen-Silag S. p. A.2730 rub.order
  • Resolor 1 mg 28 tablets Janssen-Silag S. p. A.1830 rub.order
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