Akatinol Memantine


1 tablet may include 5 mg / 10 mg / 15 mg or 20 mg memantine.

The additional composition of the substances in the tablet varies depending on the mass content of the active ingredient in it.

Release form

The medicine Akatinol Memantine is produced in the form of tablets in the following secondary packaging: 10 mg - No. 30 or No. 90; 20 mg - No. 28, No. 56 or No. 98. Also, one of the forms of release of the drug is a tablet set No. 28, which includes 7 tablets with different mass contents of memantine (5 mg, 10 mg, 15 mg, 20 mg).

Pharmachologic effect

Anti-dementia (for therapy dementia).

Pharmacodynamics and pharmacokinetics

Akatinol Memantine (Akatinol Memantine) is a therapeutic drug that is a non-competitive antagonist of NMDA (N-methyl-D-aspartate). Efficiency memantine develops due to its effect on glutamate ionotropic NMDA receptors, as a result of which the modulating effect of the drug is directed to the glutamatergic system.

Memantine actively involved in regulatory processes ion transportnormalization membrane potentialblocking calcium channels. Drug effects improve distribution nerve impulsesrises cognitive brain function and the patient’s daily activity increases.

Oral administration memantineleads to its rapid and complete absorption. In a period of time from 2 to 6 hours, the plasma Cmax of the drug is reached. Under normal renal function cumulation of the drug is not observed. T1 / 2 of the two phases of excretion is 4–9 hours and 40–65 hours, respectively. Excretion is carried out by the kidneys.

Indications for use

Akatinol Memantine tablets are prescribed for maintenance therapy with mixed, vascular dementia, as well as Alzheimer's type dementia (Alzheimer's disease) of any severity.


Akatinol Memantine is contraindicated in patients with:

  • personal hypersensitivity to the active component and the additional ingredients of the tablets;
  • breastfeeding;
  • expressed impaired renal function;
  • pregnancy;
  • up to 18 years (insufficient verified data).

Caution is advised to prescribe the drug with:

  • cramps(including medical history);
  • thyrotoxicosis;
  • heart failure;
  • epilepsy;
  • myocardial infarction.

Side effects

When taking the drug in some patients, the development of negative side effects was observed, including:

  • headache;
  • fatigue;
  • constipation;
  • fungal infections;
  • dizziness;
  • venous thrombosis;
  • drowsiness;
  • gait disturbance;
  • nausea / vomiting
  • confusion;
  • hypertension;
  • hallucinations (with severe dementia);
  • thromboembolism;
  • psychotic reactions (very rare);
  • pancreatitis (rarely);
  • cramps(rarely).

Akatinol Memantine, instructions for use (Method and dosage)

The tablets of the therapeutic agent Akatinol Memantine are intended for oral administration with food.

Instructions for use Akatinol Memantine involves an individual selection of the dosage regimen for each individual patient who has reached the age of 18 years (younger children are not recommended to take these tablets), with the choice of the optimal dosage during the weekly increase in the doses of the drug he takes.

Maintenance therapy for conditions dementiaIt is recommended to start with the patient taking the minimum daily dose of 5 mg during the first week. Subsequently, every 7 days, the daily dosage is increased by 5 mg, reaching the optimal daily dose of 20 mg by the fourth week of treatment. In case of acute need, a gradual (weekly 5 mg) increase in the daily dosage to 30 mg is allowed.


The negative consequences of taking high doses of Akatinol Memantine may manifest as the onset or intensification of the side effects inherent in this drug.

A set of therapeutic measures to level the negative effects of an overdose includes: gastrointestinal tract cleaningreception sorbentsand subsequent symptomatic treatment.


Combined use with anticholinergic therapeutic agents, agonists dopamine and drugs L-dopa may cause an increase in their effect.

Parallel reception with antipsychoticsand barbituratesmay decrease their effectiveness.

When taken in conjunction with Baclofenor Dantrolenea decrease or increase in their action is possible, which may require an individual selection of doses of these drugs.

Combination treatment with Dexometorphan, Ketamineand amantadine.

Concurrent appointment with kinin, Cimetidine, nicotine, quinidineand procainamidemay lead to an increase in their plasma concentrations.

In parallel with hydrochlorothiazide possibly a decrease in its serum level.

Terms of sale

Akatinol Memantine is a prescription drug.

Storage conditions

Not exceeding a temperature of 25 ° C.

Shelf life

Tablets retain their properties for 4 years.

Special instructions

In patients suffering Alzheimer's diseaseespecially in moderate to severe stage dementia, violations are often observed that do not allow them to adequately manage complex mechanisms and vehicles. In addition, the reception memantineable to change the speed of their reaction. In this regard, patients undergoing Akatinol Memantine therapy on an outpatient basis should be careful when driving complex mechanisms and vehicles.

Analogs of Akatinol Memantine

Matches for ATX Level 4 code:GinosIntellanTanakanMemorinNoojeronGinkgo bilobaBilobilMemantineMemoplantGinkomeVitrum MemoriNamenda

Analogues of Akatinol Memantine, similar to it in their main action, are represented by drugs:

  • Bilobil;
  • Ginos;
  • Vitrum Memori;
  • Gingium;
  • Intellan;
  • Tanakan;
  • Memoplant.


Drugs that include a similar active ingredient are:

  • Memantine;
  • Alzeym;
  • Noojeron;
  • Memorelle;
  • Memaneurin;
  • Memikar;
  • Memantal;
  • Memantinol;
  • Maruks;
  • Auranex;
  • Mirvedol.

For children

With official instructions, taking the drug in patients under 18 years of age is contraindicated.

With alcohol

When undergoing therapy, you should avoid taking any drinks that include alcohol.

During pregnancy and lactation

Akatinol Memantine is contraindicated lactatingand pregnant to women.

Reviews about Akatinol Memantine

On the Internet about the drug Akatinol Memantine can be found both positive and negative reviews. For elderly patients suffering Alzheimer's disease or other type dementia, this drug often becomes indispensable, but, unfortunately, it can only slow down the development of the disease and slightly improve the general condition of the patient. At this time, the means to completely relieve a person of such ailments, unfortunately, have not yet been invented.

Another frequently discussed side of Akatinol Memantine, despite contraindications in the official instructions, is its appointment to children, in order to treat their problems mental development. In this regard, the reviews about Akatinol Memantine for children are the most diverse, ranging from purely positive to sharply negative. There is also frequent evidence of the initially positive effect of the drug on the child, followed by a sharp “rollback” that returns the small patient to its original state, and sometimes even exacerbates it. In any case, the decision to prescribe this or that drug or medical procedures for children rests with their leading pediatricians and parents, who must fully approach this issue and work together on the existing problem.

Price Akatinol Memantine, where to buy

The average price of Akatinol Memantine in tablets is: 10 mg No. 30 - 1700 rubles; 10 mg No. 90 - 4300 rubles; 20 mg No. 28 - 2600 rubles; 20 mg No. 56 - 4800 rubles; 20 mg No. 98 - 8000 rubles.

You can buy the Akatinol Memantine No. 28 tablet set on average for 1,700 rubles.

  • Online Pharmacies in Russia


  • Akatinol memantine tab. p.p.o. 20mg n98Merz Pharma / Rottendorf Pharma 7962 rub.order

Pharmacy Dialog

  • Akatinol Memantine (tablets mp / rev.20mg No. 56) 5230 rub.
  • Akatinol Memantine (tablets mp / rev.20mg No. 98) 8114 rubles to order
  • Akatinol Memantine ( 10mg No. 30) 1687 rubles to order
  • Akatinol Memantine (tab./ p / o kit (5mg№7,10mg№7,15mg№7,20mg№7)) 1670 rub.order
  • Akatinol Memantine ( 10mg No. 90) 4851 rubles to order

Eurofarm * 4% discount on the promotional code medside11

  • Akatinol memantine 20 mg No. 28 tabletsRottendorf Pharma GmbH / Merz Pharm2979 rub.order
  • Akatinol memantine set 5 mg plus 10 mg plus 15 mg plus 20 mg n28 tabletsMerz Pharma GmbH & Co. KGAA1838 rub.order
  • Akatinol memantine 10 mg n90 tabletsRottendorf Pharma GmbH 5050 rub.order
  • Akatinol memantine 10 mg n30 tabletRottendorf Pharma GmbH / Merz Pharma GmbH i1806 rub.order
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Watch the video: Uso de la Memantina Alzheimer y Demencia senil (February 2020).

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