Medication

Hydrea

Structure

Hydrox urea, citric acid, lactose monohydrate, sodium hydrogen phosphate, magnesium stearate, gelatin, titanium dioxide, iron dye.

Release form

500 mg gelatin capsules in blister packs in a cardboard bundle No. 20 or in a dark glass bottle in a cardboard bundle No. 100.

Pharmachologic effect

Antitumor.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Hydroxycarbamide is an antimetabolite - a cytostatic phase-specific drug that acts in a certain phase of the cell cycle. The drug blocks the growth of tumor cells in the G1-S phase and enhances the synergistic sensitivity of tumor cells with simultaneous radiation therapy. Hydrea suppresses synthesis DNA, and for synthesis RNA protein has no effect.

Pharmacokinetics

The drug is rapidly absorbed from Gastrointestinal tract, reaching within 2 hours the maximum plasma concentration. Eating does not affect the absorption of the drug. It is characterized by a rapid distribution of tissues and body fluids, penetrates through BBB, in milk, accumulates in red blood cells and white blood cells. The drug is metabolized in the liver. The half-life is about 4 hours. It is excreted through the kidneys, both unchanged and in the form of urea, as well as through the respiratory tract in the form of carbon dioxide.

Indications for use

  • Chronic myeloid leukemia;
  • sickle cell anemia;
  • true polycythemia;
  • essential thrombocythemia;
  • acute leukemia;
  • spicy erythremia and erythroleukemia;
  • osteomyelofibrosis;
  • melanoma;
  • tumors of the head and neck (in conjunction with radiation therapy);
  • cervical cancer, ovary, placenta, breast (in conjunction with radiation therapy);
  • neoplasms of the colon, rectum, rectosigmoid connection;
  • skin melanoma.

Contraindications

High sensitivity to the drug, pregnancy and lactation, thrombocytopenia, leukopeniaup to 12 years old anemia in severe form, liver / kidney disease, sick, after chemotherapy or radiotherapy, lactose intoleranceLactase deficiency.

Side effects

Symptoms are manifested by dysfunctions and diseases of various organs and systems of the body: anemia, leukopenia, nausea, vomiting, constipation, anorexia, hyperemia, peeling and maculopapular rashes on the skin, hyperpigmentation, nail atrophy, skin allergic reactions, headache, fatigue, dizziness, disorientation, drowsiness, crampsurinary retention, general malaise, chills, dyspnea, fever.

Hydrea, instructions for use (Method and dosage)

Treatment is carried out in periodic courses, under the close supervision of a physician. The dosage of the drug and the dosage regimen depends on the type and form of the disease, the severity of the course and condition of the patient. On average, the initial daily dosage is 20-40 mg / kg, which is taken at one time. The maintenance dose varies between 10-30 mg / kg per day.

The exact dosage is calculated based on actual body weight. The effectiveness of treatment is determined by the results of a month and a half of taking the drug. In the absence of effect, the drug is canceled. If available, the drug may continue for a long period. With development anemia taking the drug can not be stopped, but in this case, it is necessary to carry out transfusion of red blood cell mass. With the simultaneous administration of the drug and radiation therapy, side effects may increase.

Overdose

With prolonged use of the drug in doses exceeding the recommended therapeutic, patients may show signs of acute dermatological toxicity: generalized intense hyperpigmentation of the skin, erythema violet, edema, stomatitis, peeling of the skin of the palms and feet.

Interaction

While taking the drug with antidepressantssedatives, antihistamines, narcotic, sleeping pills Drugs, alcohol, the effectiveness of Hydrea is reduced. Reception Cytarabine enhances the effect of the drug. When taking Hydrea with methotrexate and 5-fluorouracil their effectiveness is reduced.

Terms of sale

On prescription.

Storage conditions

At a temperature of 15 - 25 ° C.

Shelf life

5 years.

Analogs of Hydrea

Matches for ATX Level 4 code:HydroxycarbamideIrinotecanProspidineRefnotWelcadeTretinoin

Hydroxycarbamide Medak, Biosuppressin, Hydroxyurea, Hydroxyurea Apo.

Reviews for Hydrea

Hydrea is prescribed as a first-line chemotherapy drug in patients with chronic myeloid leukemia for the period of examination and decision on the issue of treatment tactics. Reviews about the drug are positive, which confirms its effectiveness. Taking the drug allows you to get hematological remission in 20-40% of patients, it causes a quick, but short-term decrease in the number white blood cells. Therefore, maintenance therapy was usually prescribed 500 mg per day or 1 g.

"... After 7 days of taking Hydrea, the white blood cells fell". "... In order to reduce white blood cells, I saw Hydrea 500 mg and Allopurinol 400 mg". Achieve cytogenetic remission (disappearance Ph chromosomes) this drug is impossible. It inhibits the development of the disease and allows you to control an elevated level for some time. white blood cells.

Failure to use Hydrea may aggravate the situation. According to reviews, the drug was well tolerated, side effects were rarely observed, and a contraindication to its purpose is peptic ulcer in the acute phase. Achieve a complete recovery in chronic myeloid leukemia it is possible by carrying out allogeneic bone marrow transplantation during the first year of the disease.

This drug is considered the treatment of choice and the “gold standard” of true treatment. polycythemia. To achieve remission, cytostatic therapy was carried out at a dose of 30 mg / kg per day in 2 divided doses, and then it was reduced by half, and the maintenance dose was 500 mg - 1 g per day. At primary myelofibrosis cytostatic therapy with this drug was performed to stop thrombocytosis and reduce the size of the spleen.

Judging by the reviews, he was most often prescribed in a daily dose of 1000 to 3000 mg, and then maintenance therapy was also carried out. "... This drug was prescribed, easily tolerated, the spleen began to decrease". With essential thrombocythemia taking the drug is aimed at normalizing the number platelet countbut always it was effective. "... I took Hydrea for a year and a half, but platelets did not decrease below 90". Of the side effects, patients noted hair loss.

Price on Hydrea where to buy

You can buy Hydrea in all pharmacies in Russian cities. The cost of Hydrea in Moscow ranges from 211-255 rubles. The price of Hydrea in the pharmacies of St. Petersburg is 209-248 rubles, in Voronezh the drug can be purchased for 232 rubles, in Krasnoyarsk for 221 rubles.

  • Online Pharmacies in Russia

ZdravCity

  • Hydrea caps. 500mg n20Bristol-Myers Squibb / Corden Pharma Latina229 rub. Order

Pharmacy Dialog

  • Hydrea (caps. 500mg No. 20) 224 rub.order

Eurofarm * 4% discount on the promotional code medside11

  • Hydrea 500 mg No. 20 caps.Corden Pharma Latina S.p.A. 247 rub.order
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Watch the video: Sickle Cell Patients and Hydroxyurea Treatment (January 2020).

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