Medication

Invanz

Structure

Ertapenem Sodium, sodium bicarbonate, sodium hydroxide.

Release form

Lyophilisate in the form of a powder of 1 g for the preparation of a solution for injection of white color in glass transparent bottles of 20 ml in a cardboard bundle No. 1.

Pharmachologic effect

Antibacterial.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

The bactericidal activity of the drug is based on the inhibition of the synthesis of the cell wall and is mediated by its ability to bind to PSB (penicillin-binding proteins). Ertapenem resistant to hydrolysis beta-lactamases core classes including cephalosporinases, penicillinase and beta lactamases. Highly active against strains of facultative anaerobic and aerobic gram-positive and gram-negative microorganisms: Streptococcus pyogenes, Staphylococcus aureus, Streptococcus pneumoniae, Streptococcus agalactiae, Haemophilus influenzae, Escherichia coli, Bacteroides fragilis, Clostridium spp., Eubacter spp., Peptostreptococcus spp., Ascharolytica porphyromonas, Prevotella spp.

Many microorganisms with wide multi-resistance to various antibiotics (cephalosporin, penicillins, aminoglycosideshighly sensitive to the drug.

Pharmacokinetics

The drug is rapidly absorbed from the site of intramuscular administration. After administration in a dosage of 1 g Cmax achieved on average after 2.5 hours. The bioavailability of Invanz is about 92% and is actively associated with blood proteins. Cumulation ertapenema with the introduction of the drug in therapeutic doses in the body is absent. Metabolized in the liver. It is excreted through the kidneys and in small quantities with feces. The average T1 / 2 of blood is about 4 hours.

Indications for use

In the complex treatment of infectious and inflammatory diseases caused by strains of microorganisms that are sensitive to the drug: infections of the abdominal cavity and pelvic organs, skin and subcutaneous tissue, urinary system, community-acquired pneumonia, bacterial septicemia.

In order to prevent the development of surgical infections in colorectal surgery.

Contraindications

High sensitivity to the drug or to others beta-lactam antibiotics, age up to 3 months. Using lidocaine hydrochloride for dilution of lyophilisate, the drug is contraindicated in patients with severe arterial hypotension and with heart disease, accompanied by a violation of intracardiac conduction. Use with caution during of pregnancy and lactation.

Side effects

Allergic reactions, nausea, vomiting, post-infusion thrombophlebitis, headache, diarrhea, drowsiness/insomniaweakness / fatigue, dizzinessdecrease HELLcramps, dry mouth, candidiasis oral mucosa, belching, abdominal pain, taste perversion, itching of the skin and rashes, vaginal candidiasis, feverswelling colitisraising bilirubin, leukopenia, thrombocytopenia, erythrocyturia.

Invanz, instructions for use (method and dosage)

The drug Invanz (invanz) is administered in the form of a / m injection or iv infusion. The daily dose for adults and children over 12 years of age is on average 1 g, administered once a day. Children from 3 months to 12 years old at a dosage of 15 mg / kg2 times a day. The duration of iv infusion is at least 30 minutes. The average duration of treatment is 3-14 days, depending on the type of disease, the severity and type of pathogen.

Before administration, the powder of the drug must be dissolved and diluted. To prepare a solution for iv infusion, it is recommended to use sterile water or a 0.9% solution sodium chloride. When preparing the Invanz solution for iv infusion, it is forbidden to mix the drug with other drugs, as well as to use solvents, which include glucose.

For the preparation of a solution for intramuscular injection, a solution is used lidocaine hydrochloride. Enter deep into the lateral muscles of the thigh or gluteal muscles. You can not use a ready-made solution for IM injection for intravenous administration of the drug.

Long-term treatment with Invanz can lead to the growth of microorganisms that are insensitive to the drug.

Overdose

There is no evidence of an overdose of the drug.

Interaction

When used together ertapenema and drugs blocking tubular secretion, change the dosage is not required. Simultaneous use ertapenema from sodium divalproate or valproic acid reduces concentration valproic acid, which increases the risk of a seizure. Reliable Interaction Data ertapenema with any drug except Probenecidare absent.

Terms of sale

On prescription.

Storage conditions

Store unopened vials at temperatures up to 25 ° C. Solutions of the drug should not be frozen. The prepared solution for IM injection should be stored for no more than 1 hour.

Shelf life

24 months.

Invanza Analogs

Matches for ATX Level 4 code:MeronemMeropenemChienam

Drugs with a similar pharmacological effect include: Europenem, Lastinem, Mepenam, Inemplus, Merobocide, Meromek, Merospin, Prepenem, Ronem, Chienam, Sinerpen and others.

Inwanza Reviews

Reviews of the drug in most patients are positive. The drug is effective in many infectious and inflammatory diseases.

"... The doctor prescribed the antibiotic Inwanz after the diagnosis of pyelonephritis. Pricked the drug for 9 days. The effect is good, pain in the lumbar region disappeared, the temperature returned to normal, and the tests improved significantly. Great drug".

Of the negative aspects, many patients note its high cost.

Invanza price, where to buy

The price of the lyophilisate Invanz 1 g for injection varies between 2365 - 3520 rubles per package. You can buy Invanz in most pharmacies in Moscow and other cities without problems.

  • Online Pharmacies in Russia
  • Online pharmacies in UkraineUkraine

LuxPharma * special offer

  • Invanz lyophilisate d / preparation r-ra d / injection 1g 20ml fl 1pc 6,700 rub.order
show more

Pharmacy24

  • Invanz 1 g N1 vial lyophilizate Merck Sharp i Dome B.V., Netherlands / Laboratory Merck Sharp i Dome Shibre, France 1223 UAH to order

Pani Pharmacy

  • Invanz bottle Invanz lyophilisate for solution for injection 1g bottle No. 1 France, Lab. Merck Sharp & Dohme Chiber 1413 UAH order
show more

Watch the video: Starting Invanz (January 2020).

Popular Posts

Category Medication, Next Article

Bismuth tripotassium dicitrate
Active substances

Bismuth tripotassium dicitrate

Chemical name Bismuth (III) salt of potassium 2-hydroxy-1,2,3-propanetricarboxylate Chemical properties Colloidal bismuth subcitrate belong to the group of antacids and adsorbents. The substance is usually found in coated tablets. Its molecular weight is 704 g per mole. Pharmacological action Enveloping, antibacterial, gastroprotective, antiulcer.
Read More
Proline
Active substances

Proline

Chemical name L-pyrrolidine-2-carboxylic acid Chemical properties Proline is a heterocyclic amino acid in which the nitrogen atom is part of a secondary amine. There are 2 optical isomers of the amino acid D-proline and L-proline, another substance is in the form of a racemate. The molar mass of the compound = 115.1 grams per mole, the density of the substance is from 1.35 to 1.38 grams per cm ^ 3.
Read More
Fenspiride
Active substances

Fenspiride

The chemical name is 8- (2-Phenylethyl) -1-oxa-3,8-diazaspiro [4,5] -decan-2-one. Usually the substance is in a lek. means in the form of hydrochloride. Chemical properties Fenspiride is a widespread bronchodilator. Most often it is used as part of the complex treatment of bronchial asthma and infectious and inflammatory diseases of the respiratory tract.
Read More
Phenylpropanolamine
Active substances

Phenylpropanolamine

Chemical name (±) - (R, S) -alpha- (1-aminoethyl) benzenemethanol Chemical properties Phenylpropanolamine is a stereoisomer of cathine, an organic alkaloid. Present in the form of hydrochloride in medicines. Molecular mass of the substance = 151.2 grams per mole. Melts at 53 degrees Celsius. The substance is also called norephedrine.
Read More