Medication

Colchicum Dispersion

Structure

In 1 tablet of colchicum seed extract 15.6 mg (corresponding to 500 mcg colchicine) Lactose monohydrate, MCC, corn starch, copovidone, palmitic acid, shellac, magnesium stearate, gum arabic, povidone, magnesium oxide, macrogol, sucrose, titanium oxide, talc, sodium carmellose, amaranth (E123), white wax and carnauba sulfide, sodium carnauba, sodium as excipients.

Release form

Coated tablets of 0.5 mg.

Pharmachologic effect

Anti-gout.

Pharmacodynamics and pharmacokinetics

Pharmacodynamics

Alkaloidisolated from colchicum has analgesic and anti-inflammatory effects. Affects uric acid metabolism. Suppresses division granulocytesreduces migration white blood cells in the inflammatory focus, inhibits the formation leukotriene and delays deposition uric acid in the tissues. Inhibits development amyloidosisbecause it reduces education amyloid fibrils.

In the first 12 hours of treatment for an attack of gout, 75% of patients significantly improve their condition. However, many have adverse reactions before clinical improvement. In a daily dose of 2 mg daily intake, the likelihood of repeated attacks decreases. Also prevents acute family attacks Mediterranean fever.

Pharmacokinetics

Rapidly absorbed from Gastrointestinal tract. The maximum concentration is determined 70 minutes after administration. It penetrates well into tissues, the highest concentrations are determined in the liver, spleen, kidneys, Gastrointestinal tract, white blood cells. It is metabolized in the liver, most of it is excreted in the feces of the intestines and 23% in the urine. T1 / 2 about 9.3 hours

Indications for use

  • acute attack gout;
  • prophylaxis of attacks (use with uricosuric preparations);
  • Behcet's disease;
  • periodic illness;
  • scleroderma;
  • chondrocalcinosis.

It is used only as directed by a doctor.

Contraindications

  • hypersensitivity;
  • pronounced renal/liver failure;
  • inhibition of bone marrow hematopoiesis;
  • pregnancy.

Persons of old age and patients suffering from diseases of the kidneys, cardiovascular system are prescribed only in the form of assistance.

Side effects

  • stomach pains diarrhea, nausea, vomiting;
  • leukopenia in rare cases;
  • myoneuropathy with prolonged treatment;
  • hypoplastic anemia, agranulocytosis;
  • alopecia and skin changes.

Colchicum-Dispert, instructions for use (Method and dosage)

The tablets are swallowed whole with a large amount of liquid.

Acute attack gout - take 2 tablets (1 mg), followed by 1-3 tablets every 2 hours until pain is relieved. Daily dose no more than 16 tablets. In order to prevent attacks, several months (usually 3 months) are taken in parallel with uricosuric preparations 1-3 tablets once a day or every other day.

Treatment is carried out under hematological control. When side effects occur (usually from Gastrointestinal tract) the dose is reduced or canceled. With a decrease in level white blood cells and platelet count treatment is stopped until normalization.

Overdose

Chronic intoxication is observed after taking 10 mg or more for several days. Acute intoxication after taking 20 mg. Affects organs with a high proliferation rate.

Intoxication is manifested by burning in the throat, urge to vomit, nausea, thirst, urge to urinate, tenesmus and colic, which appear 2-6 hours after taking a toxic dose.

Hemorrhagic diarrhea causes loss of fluid and electrolytes, hypokalemia, hyponatremia and acidosis. Complaints of tightness and pain in the heart appear. Pallor is noted cyanosis and dyspnea, tachycardia and hypotension and possible collapse.

There is also a decrease in sensitivity, convulsions and paralysis. After intoxication, complete alopecia, sometimes impaired renal and liver function, cases of blindness.

Symptomatic treatment is carried out. Induce vomiting or gastric lavage, apply Activated carbon. Plasma substitutes are administered intravenously, glucose and electrolytes (mainly potassium). With a decrease in myocardial contractility, cardiac glycosides are prescribed. With increased pressure of the cerebrospinal fluid, lumbar puncture is sometimes performed. Artificial respiration may be necessary. The entire period of treatment monitors the function of the bone marrow of the liver and kidneys.

Interaction

Compatible with allopurinol and uricosuric drugs. When used with macrolides, there is a risk of nephrotoxicity. Reduce the activity of this drug cytostatics and urine acidifying drugs.

The opposite effect is exerted by drugs that alkalinize urine. When combined with Vit. AT 12 the absorption of the drug from Gastrointestinal tract. Drugs that cause myelodepressionfurther increase the risk leukopenia and thrombocytopenia.

Terms of sale

On prescription.

Storage conditions

Temperature up to 25 ° С.

Shelf life

5 years.

Analogs of Colchicum Dispersion

Matches for ATX Level 4 code:Colchicine

Pills Colchicine.

Reviews of Colchicum Dispersion

Treatment of gout comes down to stopping the attack and systematic treatment of purine metabolism disorders. For stopping apply NSAIDs (recently selective) and Colchicum-Dispert medicine containing alkaloid colchicine. Appointment colchicine - the ancient method of stopping the attack and the effect is pronounced if applied in the first hours of the onset of the attack. A drug Colchicum-Dispert promote reverse development arthritis for several hours, but it should be taken every 2 hours until the pain subsides per day no more than 16 tablets. Due to the occurrence of adverse reactions, patients often fail to increase the dose to the optimum - nausea develops, diarrheavomiting hemorrhagic gastroenteritis. In view of the toxicity of the drug, a combination of small doses is often prescribed colchicine and NSAIDs. It must be remembered that the toxicity of these drugs increases in people with kidney disease. Reviews most often relate to the use of the drug with gout. All note a rapid relief of the pain symptom.

  • "... The drug is not cheap, but it really helps. I’ve tried a lot of the disease over many years, but this is the only drug that I save".
  • "... It is very effective, but you have to buy the original German (relatives brought to me). Many fakes that do not help".
  • "... I used it and was always effective in an attack. It really helps, but not always found in the pharmacy".
  • "... Quickly relieves pain and eliminates joint swelling".
  • "... I apply the first day - it became a little easier".
  • "... I didn’t cause any side effects".
  • "... Quickly relieves an acute attack, but pains in the kidney area immediately appear".

Colchicum Dispersion price, where to buy

You can buy Colchicum-Dispert in some pharmacies. The cost of 20 tablets is 1176-1872 rubles.

  • Online Pharmacies in Russia

Pharmacy Dialog

  • Colchicum-dispersion (tab./pr. No. 20) 1102 rubles.order

Eurofarm * 4% discount on the promotional code medside11

  • Colchicum-dispersion No. 20 tablHaupt Pharma Vuelfing GmbH / Pharmaselect In1190 rub.order
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Watch the video: Turdus MerulaColchicum Autumnale (January 2020).

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