Medication

Polyoxidonium

Structure

In the composition of one pills Polyoxidonium includes 12 mg of active ingredient azoximer bromideas well as potato starch (Amylum solani), lactose monohydrate (Lactose monohydrate), stearic acid (Acidum stearicum) as auxiliary components.

In one lyophilisate vial contains 6 mg of the active substance, as well as mannitol (E421 Mannit), povidone (Povidonum) and beta-carotene (Betacarotenum) as auxiliary components.

To make one rectal vaginal suppository use 6 or 12 mg of active ingredient and auxiliary components: mannitol (E421 Mannit), povidone (Povidonum), beta-carotene (Betacarotenum), cocoa butter (Butyrum Cacao).

Release form

Polyoxidonium has three dosage forms:

  • pills;
  • rectal-vaginal suppositories;
  • lyophilized powder.

Suppositories are in the form of a torpedo, painted in a light yellow color and specifically smell like cocoa butter.

The tablets are flat-cylindrical, on each of them there is a chamfer. Their color can vary from yellowish-white to orange-yellow. In tablets, the presence of slightly noticeable particles of a more intense color is allowed.

Pharmachologic effect

Polyoxidonium belongs to the group of drugs that have immunocorrective and detoxifying effects.

Pharmacodynamics and pharmacokinetics

Polyoxidonium (or azoximer bromide) helps to increase the body's resistance against infections caused by viruses, bacteria or fungi.

The mechanism of its action is associated with the ability of a substance to act on phagocytic cells and NK cells (natural or natural killers), and also stimulate the process of antibody formation.

The drug helps to restore the immune status in secondary immunodeficiency conditions, which are caused by various kinds of infections, injuries, burns, malignant tumors, complications after surgery, treatment with chemotherapeutic drugs, including including cytostatic agents and steroid hormones.

Along with immunocorrective action azoximer bromide also has a pronounced detoxifying effect, which is due to the structure and high molecular nature of this substance.

The result of its effect on the body is to increase resistance cell membranes to the cytotoxic (causing damage to cells up to their death) action of drugs and chemicals, as well as a decrease in the toxicity of the latter.

The appointment of Polyoxidonium in combination with other drugs increases the effectiveness of therapy by an order of magnitude, shortens its duration, reduces doses or avoids the use antibiotics, bronchodilator and glucocorticosteroid drugs, helps to increase the period of remission (that is, the period of weakening or complete disappearance of the symptoms of the disease).

Polyoxidonium is well tolerated by patients, does not show mitogenic or polyclonal activity, does not have antigenic properties, does not provoke development allergies, mutations and others fetal development defectsdoes not possess teratogenic effect on a developing fetus, does not have carcinogenic and embryotoxic properties.

Azoximera bromide characterized by high bioavailability, which is about 89 percent. With intramuscular injection of Cmax in blood plasma observed 40 minutes after the injection.

The substance is quickly distributed in the tissues. In the body azoximer bromide biotransformed. Its elimination is carried out mainly by the kidneys.

Indications for use

Indications for use of tablets

Adult patients and adolescents over 12 years old Polyoxidonium tablets prescribed, as a rule, in addition to the therapy used.

The medicine is indicated for acute and chronic recurrent inflammatory and infectious diseases in the oral cavity, paranasal sinuses, upper respiratory tract, in the inner and middle ear.

Immunocompromised patients (patients with secondary immune deficiency) Polyoxidonium is prescribed to be taken sublingually as a monotherapeutic agent for prevention flu and others acute respiratory infections in the period preceding seasonal epidemics.

Indications for use of lyophilisate

Solution, which is prepared from lyophilized powder, is intended for insertion into a muscle or vein, as well as for external use.

For adult patients, it is prescribed as an addition to the main therapy for:

  • resistant to standard therapy of inflammatory diseases of various origins during their exacerbation and in remission (including chronic and recurrent diseases);
  • rheumatoid arthritis (in case the patient underwent long-term treatment immunosuppressive drugs);
  • complicated ARI or SARS, rheumatoid arthritis;
  • acute or chronic infectious diseases provoked by the activity of viruses or bacteria (including diseases of the urogenital tract);
  • tuberculosis;
  • diseases of an allergic nature that are complicated by a chronic recurrent bacterial or viral infection;
  • background states ray or chemotherapy malignant neoplasms.

As an addition to the main therapy, Polyoxidonium is used in cases where it is necessary to reduce hepato- and nephrotoxic effect of drugs. Since the drug stimulates tissue regeneration, its use is also advisable for treatment burns, bone fractures and trophic ulcers.

Monotherapy with injections of Polyoxidonium is indicated:

  • to prevent development infectious complications in the postoperative period;
  • for correction secondary immunodeficiencythat are a consequence of the aging of the body or the adverse effects of external factors;
  • preventatively to prevent flu and ARI.

Children Polyoxidonium in the form of a solution is allowed to be used from six months. The drug is prescribed as an addition to the main therapy:

  • with infectious and inflammatory diseases (including including ENT diseases - adenoid vegetation, ARVIinflammation of the pharyngeal tonsils, nasal mucosa or sinuses, etc.);
  • in acute allergic reactions and toxic-allergic lesions;
  • with complications bronchial asthma;
  • with complicated purulent infection atopic dermatitis;
  • in conditions accompanied by a violation of the normal bacterial composition of the intestine;
  • for the rehabilitation of children with FBI syndrome;
  • preventatively to prevent flu and ARI.

Indications for the use of suppositories

Indications for the drug in the form of suppositories for rectal and vaginal administration are the same as for the solution. The use of suppositories is advisable for inflammatory diseases of various localization and various etiologies, arthritisfor treatment tumors, for the prevention of infectious diseases in children and the elderly.

Candles Polyoxidonium is often prescribed for the treatment of female diseases. Candles in gynecology are prescribed for cervical erosion, endometritis, leukoplakia, scoop up, salpingitis, dysplasia etc…

Contraindications

The drug is contraindicated in individuals with individual intolerance to its components.

Side effects

Side effects of the use of tablets and suppositories are hypersensitivity reactions. With intramuscular administration of the drug in some patients, redness and soreness at the injection site may be noted. After the first injections of Polyoxidonium, body temperature may increase.

Instructions for Polyoxidonium (Method and dosage)

The dose and route of administration will be determined depending on the diagnosis, the course of the disease and the age of the patient.

Instructions for Polyoxidonium tablets

The tablets are intended for sublingual (under the tongue) or oral (inside) administration. They are drunk daily, one, two or three times a day (the frequency of receptions depends on the nature of the disease and the severity of the clinical picture) 20-30 minutes before meals.

A single dose of the drug for adults - 1 tablet (equivalent to 12 mg azoximer bromide), children from 3 to 10 years old are prescribed to take 0.5 tablets per dose.

Instructions for use Polyoxidonium in the form of a lyophilisate

The solution is administered intramuscularly or by drip into a vein, applied intranasally.

For treatment acute inflammatory diseases the drug is administered daily for 3 days at a dose of 6 mg. Further injections of Polyoxidonium continue to be done every other day. Typically, a patient needs five to ten injections.

For treatment chronic inflammatory diseases and rheumatoid arthritis the first 5 injections are done every other day, then the drug is continued to be administered 2 times a week. A single dose of the active substance is 6 mg. A full course involves at least ten injections.

Patients diagnosed tuberculosis, appoint 6 mg of the drug 2 times a week. The full course is from ten to twenty injections.

Patients with diseases of the urogenital tract ten injections are recommended (every other day). Single dose - 6 mg. Therapy is supplemented by an appointment chemotherapy.

According to a similar scheme, patients with chronic relapsing are also treated. herpes. In this case, Polyoxidonium is prescribed in combination with stimulators of the synthesis of endogenous interferon, antiviral agents, drugs interferon.

Therapy proceeding in a complicated form allergic diseases involves the introduction of five single doses of the drug to the patient (6 mg). The first two injections are recommended daily, the remaining three injections are done every other day.

At allergies and toxic allergic lesions shows an intravenous dose of 6-12 mg in combination with drugs that have anti-allergic effects (including with Clemastine).

Patients undergoing the course chemotherapy (and also after its completion) to reduce the specific effect of chemotherapeutic agents, the drug is prescribed in a dose of 6-12 mg. It is considered optimal to conduct at least ten injections (maintaining a daily interval between them).

For the correction of immunodeficiency after radiation and chemotherapy, after surgical removal of the tumor the patient is administered a dose of 6 mg 1-2 times a week. The course of treatment is quite long - usually from 2-3 to 12 months.

According to the instructions for use, injections of Polyoxidonium in patients with acute renal failure administer the drug is allowed no more than 2 times a week.

To prepare a solution for intramuscular injection, 6 mg of the active substance (the contents of one ampoule or vial) is combined with 1.5-2 ml of a NaCl solution or water for injection.

A solution for drip into a vein is prepared by mixing the contents of one ampoule or vial with 3 ml of NaCl solution, Haemodesisplasma-replacing drug Reopoliglyukina or 5% glucose solution. The resulting solution must be transferred under sterile conditions to a vial with any of these solutions with a volume of 0.2-0.4 liters.

The solution for parenteral administration must be used immediately after preparation, it is not subject to storage.

Intranasal use is indicated for acute and chronic infectious ENT diseases, to accelerate the regeneration of mucous membranes, to prevent the development of complications and relapses of diseases, and the prevention of influenza and respiratory diseases.

To prepare a nasal solution, 6 mg of lyophilisate is combined with one milliliter (20 drops) of distilled water, a solution of NaCl or ordinary boiled water. In this case, the temperature of the liquid should be room temperature.

The solution is injected at least 3-4 times during the day into each nasal passage, keeping 2-3 hours between instillations. A single dose is from 1 to 3 drops in each nostril. Treatment is continued for five to ten days.

After dilution, the drug remains stable during the day, after which it can not be used.

Candles Polyoxidonium, instructions for use

Suppositories 12 mg and 6 mg are administered rectally, after a bowel cleansing procedure, once a day (at bedtime). A single dose is one suppository. The scheme of their introduction is as follows: daily one by one in the first 3 days, then - also one by one - after 2 days. A complete course requires 10 suppositories.

Intravaginal use is indicated for the treatment of gynecological diseases: dysplasia, erosion, cervical leukoplakia, colpites, adnexitis, endometritisas well as diseases provoked human papillomavirus (HPV).

Treatment involves daily administration for three days, one suppository with a dosage of 12 mg of active substance, after which the suppository continues to be administered every other day. The course is carried out using 10 suppositories. In cases where it is appropriate, the course of treatment is allowed to be repeated after 3-4 months.

Patients diagnosed with chronic immune deficiency (including patients who have a similar condition oncological disease) Polyoxidonium is prescribed as a maintenance agent in a dose of 6 or 12 mg (according to the doctor’s testimony) 1-2 times a week. The treatment is long.

Overdose

There is no evidence of an overdose of Polyoxidonium in the form of tablets or suppositories. When using the solution in prescribed therapeutic doses, cases of overdose were also not recorded. Potentially, an increase in side effects is possible.

In case of signs of an overdose, symptomatic therapy is recommended.

Interaction

The use of Polyoxidonium in combination with antibioticsantiviral and antihistamines antimycoticscytostatic, glucocorticosteroid and bronchodilator drugs, β-adrenostimulants.

If it is necessary to introduce a solution by the drip method into a vein, it should not be diluted with infusion solutions, in which proteins are present.

Terms of sale

Tablets and suppositories are classified as over-the-counter drugs; a prescription is required to purchase a lyophilisate.

Storage conditions

Pills stored at a temperature not exceeding 25 ° C. Keep out of the reach of children.

Suppositories Listed B. It is recommended to store them in a dry, dark place. Keep out of the reach of children. The optimum temperature regime is from 2 ° to 15 ° C.

Lyophilisate should be stored in a dry, dark place. The optimum temperature regime is from 4 to 8 ° C. Keep out of the reach of children.

Shelf life

2 years.

Analogs Polyoxidonium

Matches for ATX Level 4 code:RidostinRoferon ALeucogenGenfaxonEstifanSeptilineInferonNeupogenLipoferonLiferonSodium NucleinateIntron ABetaferonNeupomaxGranocyteGeponImudonLavomaxImmunocindGrippferon

Analogues of the drug by the mechanism of action: Actinolysate, Anaferon, Arpetolid, Arpeflu, Affinoleukin, Bestin, Bioaron, Broncho Vaxom, Vilosen, Gepon, Gerbion, Glutaxim, Isophone, Immunal, Immunofan, Neuroferon, Ribomunil, Taktivin, Florexil, Cycloferon, Tsitovir-3, Engistol, Polyimuramil, Ismigen.

Polyoxidonium for children

In pediatric practice, the use of tablets is allowed from 3 years, suppositories are used from the age of six, the lyophilisate is used from six months.

Children Polyoxidonium is prescribed as an addition to the main therapy. Indications for use are acute and chronic infectious and inflammatory diseases (including including ARVI and ENT diseases), allergy and toxic allergic conditionscomplicated by chronic infectious processes in the respiratory tract, bronchial asthmaproceeding with complications (including complicated by purulent infection) atopic dermatitis, dysbiosis.

For children included in the FWB group, the drug is used to accelerate the process of their rehabilitation. In addition, Polyoxidonium has a prophylactic effect against flu and colds.

Tablets are taken sublingually or orally in a dose of 6 mg (half a tablet), daily, with a multiplicity of applications of 1, 2 or 3 times a day.

The optimal dose, number and frequency of injections is determined depending on the diagnosis and age of the child:

  • With acute inflammatory diseases five to seven injections are indicated every other day. Dose - 100 mcg / kg. If the disease is chronic, the dose is increased to 150 mcg / kg. The drug is administered every other day. The course involves the introduction of up to ten single doses.
  • For treatment allergies and toxic allergic conditions a drip of the drug into a vein at a dose of 150 mcg / kg is indicated. Therapy is supplemented by an appointment Clemastine and other drugs that have anti-allergic effects. If the disease proceeds with complications, injections are prescribed as an adjunct to basic therapy. The patient is shown 5 intramuscular injections at a dose of 100 μg / kg. The interval between administrations is 1-2 days.

A solution for intramuscular administration is prepared by dissolving 3 mg of the drug in 1 ml of NaCl solution (water for injection can be used).

A solution for intravenous administration is prepared by diluting 3 mg of the drug in 1.5-2 ml of NaCl solution, 5% glucose solution, Polyglukin or Haemodesisthen, under sterile conditions, add to the bottle with one of these solutions with a volume of 0.15-0.25 l.

Intranasally Polyoxidonium is used daily for five to ten days, instilling it at least 3-4 times a day in each nostril in a dose equal to from 1 to 3 drops. The daily dose is 150 mcg / kg body weight. The interval between procedures is 2-3 hours.

To prepare a solution for topical application, 1 ml (equivalent to 20 drops) of a room temperature liquid (0.9% NaCl solution, distilled or ordinary boiled water) is added to 3 mg of the drug.

For children, the solution is prescribed in a dose of 150 μg of active substance per kilogram of body weight (such an amount is contained in one drop of solution).

Sublingually, the drug is prescribed to be taken daily for 10 days. The daily dose for all indications is 150 mcg / kg. If the drug is used to treat dysbiosis, the course lasts, as a rule, from 10 to 20 days.

The solution is stored in the refrigerator for no more than one week. Before instilling the drug, the pipette with the solution must be warmed to room temperature.

According to the instructions for candles for children, the drug in this dosage form is allowed to be used rectally for the treatment of patients older than 6 years. Suppositories according to the doctor’s indications are administered one daily or one day before bedtime.

Candles Polyoxidonium for children - testimonials to this confirmation - an effective means, however, to achieve the desired effect from their use is possible only in cases where the treatment regimen is selected by an experienced doctor and takes into account the characteristics of the disease and the body of a particular child.

Use for pregnant and lactating women

There are no data on the safety of the use of Polyoxidonium in pregnant and lactating women, and therefore the drug is not prescribed for these categories of patients.

Polyoxidonium Reviews

Reviews about the drug are mostly positive. This is due to the fact that it effectively treats chronic and complicating diseases that cannot be treated using standard therapy.

Reviews on Polyoxidonium in suppositories, tablets and solution are evidence of the effectiveness of each of these dosage forms. Against the background of the use of the drug in complex therapy, the patient recovers faster, and the disease proceeds in a much milder form.

Using a medicine as a prophylactic for children can reduce the incidence of diseases. Reviews of doctors on Polyoxidonium allow us to conclude that this remedy is really irreplaceable.

Prescribing candles, tablets or a nasal solution to children helps to more quickly adapt to staying in a team (at school or kindergarten). At the same time, children are much less susceptible to infections, even during seasonal epidemics.

Most of the positive reviews for Polyoxidonium in suppositories and other dosage forms are due to the fact that the drug is convenient to use, well tolerated by children and practically does not cause side effects.

Adults Polyoxidonium is most often prescribed for the treatment of infectious diseases. The use of suppositories in gynecology in combination with the main therapy contributes not only to the effective elimination of the symptoms of the disease, but also significantly increases immunity and, accordingly, helps prevent relapses and complications.

After analyzing the reviews about the injections of Polyoxidonium, we can confidently say that the drug has a positive effect even in fairly complex cases when the patient’s body is weakened oncological diseaseand his treatment.

Rare negative reviews are associated with the fact that the drug did not give visible changes in the patient’s condition, which in some cases may be the result of an incorrectly selected intake regimen that does not take into account the individual characteristics of the patient’s body.

The reviews indicate the high cost of Polyoxidonium, however, given that the drug is effective, helps quickly and for a long time, facilitates the course and reduces the frequency of diseases, does not cause pain during administration (this applies to all dosage forms except for injections, the latter, on the contrary, are very painful) , this "drawback" for most patients fades into the background.

Price Polyoxidonium, where to buy

The average price of Polyoxidonium tablets is 540 UAH. The price of candles Polyoxidonium 12 mg - 750 UAH, you can buy candles 6 mg on average 580 UAH. The price of Polyoxidonium in ampoules (injections of 6 mg) - from 600 to 1200 UAH.

You can buy 12 mg tablets in Moscow on average at 660-750 rubles. The price of ampoules 6 mg - from 950 rubles. Candles 6 mg cost about 750 rubles, candles 12 mg - 850 rubles.

  • Online Pharmacies in Russia
  • Online pharmacies in Kazakhstan

ZdravCity

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  • Polyoxidonium supp. vag / rect 6mg n10Petrovax Farm NPO OOO939 rub.order
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  • Polyoxidonium lyoph. d / in. and local 6mg n5 (fl) Petrovax Farm NPO OOO 1351 rub.order
  • Polyoxidonium tab. 12mg n10Petrovax Farm NPO OOO770 rub.order

Pharmacy Dialog

  • Polyoxidonium (fl. 0,006g No. 5) 1320 rubles to order
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  • Polyoxidonium (fl. 0,003g No. 5) 850 rubles to order
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Eurofarm * 4% discount on the promotional code medside11

  • Polyoxidonium lyophilisate for injection 3 mg n5Petrovax Farm NPO, OOO807 rub.order
  • Candle Polyoxidonium 6 mg n10P.P. Scherer GmbH & Co. KG 962 rub.order
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BIOSPHERE

  • Polyoxidonium 3 mg No. 5 por.liof.d / in. bottle Petrovax Farm LLC NPO (Russia) 4 tg.
  • Polyoxidonium 12 mg No. 10 supp.Petrovaks Farm OOO NPO (Russia) 8 tg.order
  • Polyoxidonium 6 mg No. 10 supp.Petrovaks Farm OOO NPO (Russia) 6 tg.order
  • Polyoxidonium 6 mg No. 5 por.liof.d / in. bottle Petrovax Farm LLC NPO (Russia) 7 tg.order
  • Polyoxidonium 12 mg No. 10 tablets Petrovax Pharm LLC NPO (Russia) 4 tg.
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Watch the video: Полиоксидоний для иммунитета. (January 2020).

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