International name of the drug (INN): Bromo dihydrochlorophenylbenzodiazepine.
Part Phenazepam in tablet form includes:
- 0.0005, 0.001 or 0.0025 g phenazepam (bromodihydrochlorophenylbenzodiazepine);
- milk sugar (lactose);
- potato starch;
- povidone (collidone 25);
- calcium stearate;
In 1 ml Phenazepam ampoules contains:
- 0.001 g phenazepam (bromodihydrochlorophenylbenzodiazepine);
- polyvinylpyrrolidone low molecular weight medical (povidone);
- glycerin (glycerol) distilled;
- sodium disulfite (sodium pyrosulfite);
- polysorbate 80 (tween 80);
- sodium hydroxide solution (sodium hydroxide) 1 M;
- water for injections.
Phenazepam is available in tablet form and in solution for intramuscular or intravenous administration.
Phenazepam tablets are white, flat-cylindrical, with a bevel. On tablets containing bromodihydrochlorophenylbenzodiazepine at a dose of 1 mg, there is also risk.
The solution for intramuscular and intravenous injection is available in glass ampoules with a capacity of 1 ml. Packaging:
- cardboard box with 10 ampoules of phenazepam and a scarifier;
- blister PVC packaging with 5 or 10 ampoules of the drug.
A cardboard pack is completed with one or two packages, a scarifier and instructions for use of the drug.
For hospitals, Fenazepam is available in cardboard boxes with a cardboard grate. In one box, there can be 50 or 100 ampoules with a solution.
Phenazepam belongs to the pharmacotherapeutic group anxiolytics (other names of the group are tranquilizers, psycho-sedative agents, ataractics, antineurotic drugs).
Anxiolytics and, in particular, Phenazepam are psychotropic drugs. with the ability to reduce severity or suppress anxiety, fear, anxiety, relieve emotional stress.
Phenazepam has the ability to have effects:
- muscle relaxant;
Phenazepam - what is it?
According to Wikipedia, Phenazepam or bromodihydrochlorophenylbenzodiazepine It is a powder with a crystalline structure, white or white with a light cream tint. The substance is practically insoluble in ethers and water, slightly soluble in ethanol and sparingly soluble in chloroform.
Phenazepam was created by Soviet scientists more than 40 years ago and was originally used exclusively for medical purposes as a highly active tranquilizer.
In particular, the drug has been widely used in military medicine. Also, the drug is used to treat epileptic seizures, sleep disorders, depressions, alcohol withdrawal etc…
In pure form drug provokes the most varied (sometimes opposite) effects:
- feeling of great drowsiness;
- a surge of positive emotions;
- increased aggression;
- bitterness, etc ...
Is Phenazepam addictive?
Even with proper use for medicinal purposes in compliance with the recommended dosage, the drug can be highly addictive, and after prolonged continuous use, a person develops a strong addiction, the result of which can be serious disorders nervous system.
What is dangerous phenazepam?
If at the initial stages of using the drug, a person has drowsiness and positively colored emotions, then after some time (with continuous use of Phenazepam), positive emotions are replaced by negative ones.
People who abuse Phenazepam suffer from hallucinations, delusions, fear and sleep disorders. Some may even have obsessive suicidal thoughts. On slang, such a psychedelic crisis is most often called a bad trip (or just a bad trip).
Phenazepam as a drug
As a drug, Phenazepam is most prevalent in Western Europe and, in particular, in the UK. In its pure form, it is rarely used, due to the unpredictability of the action. bromodihydrochlorophenylbenzodiazepine on the body. So, on the forums where drug addicts communicate, you can find reviews of the following kind: “How rushing Phenazepam ?! If you're lucky, then a few days”.
Even for therapeutic purposes, phenazepam tablets given to the patient by the doctor before the surgery in some cases can provoke an inhibition effect that lasts up to three days.
Most often, drug addicts use Phenazepam to relieve breakdowns, in cases where it is not possible to find other drugs, and also just to fall asleep normally.
The prevalence of the drug is due to its cheapness and relatively high rate of effectiveness. Also contributing to this is the fact that phenazepam can be purchased according to the usual prescription.
Many drug addicts, however, wonder over time “How to get off Phenazepam?" The withdrawal of the drug is a very responsible step. For this reason, before you stop taking it, the patient should visit a doctor, undergo an examination and pass the necessary tests.
It is optimal to carry out the abolition of Phenazepam in a hospital environment, especially when there is no full confidence that the patient will comply with all the doctor's recommendations. However, outpatient treatment is also allowed.
Modern narcology offers several methods of drug withdrawal:
- Conducting a provocative test using pentobarbital.
- Phenobarbital Equivalent Method, which is used in cases where the addict refuses hospitalization, but at the same time wants to recover from his dependence.
- A method involving the use of a saturating dose (for which Phenazepam is given to the patient for a short period of time in new and new doses).
The purpose of the first two methods is to determine the needs of the dependent person barbiturates. The third allows you to provoke easy body intoxication.
In this case, the patient must be informed about the inevitable consequences of therapy, which are expressed in the form tachycardia, nightmares, impaired coordination of movements, general malaise, etc ...
In some cases, the sensations can be so unpleasant that the patient does not stand up and throws the treatment. And even if it is successfully completed, some may have relapses. Complete elimination of dependence is possible only if the person himself wants to get rid of his ailment.
Pharmacodynamics and pharmacokinetics
Pharmacodynamics of Phenazepam
The effects of phenazepam are due to the ability diazepines affect the various parts of the central nervous system.
The anxiolytic effect of the drug is due to the influence bromodihydrochlorophenylbenzodiazepine on amygdala complex of the visceral brain (limbic system).
It manifests itself in reducing the decrease in emotional tension, relieving anxiety, fear and anxiety. In its anxiolytic properties, Phenazepam is significantly superior to most other psychotropic drugs of the diazepine series.
Sedative effect due to influence bromodihydrochlorophenylbenzodiazepine on the nerve structures in the central departments brain stem (reticular formation of the brain) and forming diffuse thalamic system nonspecific thalamic nuclei.
The drug has a general calming effect on the central nervous system, reducing the severity of reactions to external stimuli, psychomotor irritability, partially reducing daily activity, lowering concentration, as well as the speed of mental and motor reactions, etc.
By regulating the function of the central nervous system, phenazepam reduces the intensity of exposure to various kinds of vegetative, motor and psychoemotional stimuli that affect the mechanism of falling asleep.
Hypnotic effect is expressed in the fact that on the background of treatment with the drug, the onset of sleep is significantly facilitated, the sleep deepens, and its duration increases.
In addition, due to its inhibitory effect on the central nervous system, the drug has the ability to potentiate the effects sleeping pills, anesthetic and pain medication(why phenazepam tablets are not prescribed in combination with these drugs).
Phenazepam action as muscle relaxant (i.e. skeletal muscle relaxant) is mainly due to the ability bromodihydrochlorophenylbenzodiazepineinhibit polysynaptic (and to a lesser extent - monosynaptic) spinal-stem reflexes.
What helps Phenazepam, acting as a muscle relaxant?
The drug effectively relieves (or, at least, reduces the severity) stress, relieving excitement (including motor).
However, this same property may become a limitation on the prescription of the drug to people whose work involves a certain speed of mental and physical reactions. In some cases, the muscle relaxant effect manifests itself in the form of a feeling of lethargy, increased weakness, etc ...
The action of the drug, aimed at reducing convulsive activity, is associated with an increase in presynaptic tension and suppression of the spread of a convulsive impulse (epileptogenic activity) that occurs in epileptogenic foci of the cerebral cortex, visceral brain, and also thalamus.
Anticonvulsant effect It is caused not only by the action of bromodihydrochlorophenylbenzodiazepine on GABA (gamma-aminobutyric acid - the main inhibitory neurotransmitter (neurotransmitter) in the central nervous system, which is responsible for balancing the effect of activating neurotransmitters), but also with the ability of a substance to affect the Na + channel (potential-dependent sodium channel).
It is possible that the tranquilizing, muscle relaxant and anticonvulsant effects are realized through the GABAA receptor, and hypnotic (hypnotic) effects are mediated by changing Ca2 + ion fluxes through voltage-dependent channels.
At the same time, sleep is very similar to physiological and is characterized by typical for the latter EEG stages and phases.
On the positive (productive) symptoms, which are accompanied by acute psychotic disorders (rave, hallucinations, affective states etc.) Phenazepam has virtually no effect.
In rare cases, patients may experience a decrease in affective tension and a decrease in the severity of delusional disorders.
Pharmacokinetics of Phenazepam
When taken orally, the drug is well absorbed from the digestive tract. The time for which the maximum concentration of bromodihydrochlorophenylbenzodiazepine is reached in blood plasmavaries from an hour to two.
Phenazepam is exposed metabolism in the liver, the half-life of the organism in different patients can be from 6 to 18 hours. Products metabolism excreted from the body mainly by the kidneys.
Pharmacokinetic parameters of phenazepam in the form of a solution for injection are not provided by the manufacturer.
Indications for use of the medicine:
- neurosispseudo-neurotic (neurosis-like) conditions, psychopathypsychopathic disorders and other conditions that are characterized by the appearance of feelings of fear, increased anxiety, irritability, moodiness (its lability), increased tension;
- sleep disorders;
- reactive psychosis;
- hypochondria syndromeaccompanied by various kinds of unpleasant or painful sensations (hypochondriac-senestopathic syndrome; including in cases where treatment with other tranquilizers did not give the expected result);
- autonomic dysfunction syndrome;
- prevention phobic states and conditions accompanied by feelings of tension;
- temporal and myoclonic epilepsy;
- panic reactions;
- dyskinesia, tics;
- a sharp increase in tone and stable muscle resistance to deforming forces (muscle stiffness);
- instability (lability) of the autonomic nervous system;
- alcohol withdrawal syndrome.
The annotation to the drug also indicates that Phenazepam can be used for preliminary medical preparation of patients for general anesthesia and surgical intervention.
Since Phenazepam belongs to the category of potent drugs, it has a number of contraindications and can be used to treat far from all categories of patients.
So, it is forbidden to prescribe Phenazepam:
- patients in shock or coma;
- patients suffering from manifestations myasthenia gravis;
- at angle-closure glaucoma (both during an acute attack, and people with a predisposition to the disease);
- patients diagnosed COPD (the drug can provoke an increase in respiratory failure);
- at acute respiratory failure;
- during pregnancy (especially in its first trimester);
- lactating women;
- children and adolescents under the age of 18;
- patients who have been hypersensitive to drugs of the benzodiazepine series, as well as sensitivity to any of the auxiliary components of the drug.
In patients with severe forms of impaired liver and / or kidney function, Phenazepam should be taken only under the supervision of an experienced specialist.
Also, with great caution, the drug is prescribed to people who have previously experienced addiction to drugs, psychologically dependent on certain types of drugs to people, as well as elderly patients.
Side effects of phenazepam
Phenazepam is characterized by a large list of contraindications, and the side effects that are noted while taking the drug are also quite diverse. This is due to the ability of the drug to affect the activity of the nervous system.
Most patients - especially in the initial stages of treatment - increase drowsiness, a feeling of chronic fatigue and lethargy, dizziness, impaired ability to concentrate and navigate in space, symptoms appear ataxia, the speed of mental and motor reactions slows down, consciousness gets confused.
Somewhat less often, the nervous system responds to Phenazepam:
- the appearance of headaches;
- feeling euphoria;
- depressive states;
- memory impairment;
- movement coordination disorders (especially if the drug is taken in high doses);
- decreased mood;
- dystonic extrapyramidal disorders;
- symptoms asthenic syndrome;
In very rare cases, paradoxical reactions occur in response to medication, which are expressed as uncontrolled outbreaks aggression, phobia, hallucinations, anxiety, muscle spasticity, sleep disorders, the appearance of suicidal tendencies.
The hematopoietic system can respond to phenazepam by reducing the concentration of its formed elements (white blood cells and postcellular structures, which include red blood cells and platelets), hemoglobin and neutrophilic granulocytes.
To adverse reactions that are noted by digestive systeminclude: increased dryness of the mucous in the oral cavity, salivation, loss of appetite, constipation or diarrhea, heartburn, nausea, increased activity of liver enzymes of the liver (transaminase), jaundice, increased levels of alkaline phosphatase in the blood.
By reproductive system there may be an increase or, on the contrary, a decrease in libido, women may also show symptoms dysmenorrhea. In some patients, phenazepam is accompanied allergic reactions, including the appearance of rashes on the skin and itching.
Other side effects that phenazepam triggers include:
- addiction to the drug;
- development of drug dependence;
- decline in performance blood pressure;
- visual impairment (in particular, double vision of objects in front of the eyes);
- weight loss;
- heart rhythm disturbance.
In the case of a sharp cessation of the use of phenazepam or a decrease in its dose, the so-called withdrawal syndrome, which is often expressed in the form of symptoms that led the patient to take the drug.
Phenazepam: instructions for use (Method and dosage)
Phenazepam tablets: instructions for use
Phenazepam tablets are intended for oral administration. The average daily dose of the drug, as a rule, is from 0.0015 to 0.005 g of bromodihydrochlorophenylbenzodiazepine. It is recommended to divide it into two or three doses.
In the morning and in the afternoon, the instructions for use of Phenazepam recommends taking 0.0005 or 0.001 g, in the evening the dose can be increased to 0.0025 g. The daily dose of bromidihydrochlorophenylbenzodiazepine is considered to be the most acceptable, equal to 0.01 g.
How to take pills for various diseases:
- States accompanied by sleep disturbances: the drug is taken about half an hour before bedtime in a dose equal to 0,00025 or 0,0005 g.
- Neurosis, pseudo-neurotic (neurosis-like) conditions, psychopathy, psychopathic disorders: treatment begins with a daily dose of 0.0015 to 0.003 g. It is recommended to divide it into two or three doses. After a few days (usually after 2-4 days, depending on the tolerance of Phenazepam and the effectiveness of therapy), the dose is allowed to be increased to 0.004-0.006 g per day.
- Motor anxiety, vegetative paroxysms, fromfucking, increased anxiety: treatment begins with a daily dose of 3 mg, after which the dose is rapidly increased until the desired clinical effect is achieved.
- Epilepsy: daily dose varies from 0.002 to 0.01 g.
- Alcohol withdrawal syndrome: daily dose is from 0.0025 to 0.005 g.
- Diseases accompanied by an increase muscle tone: the daily dose is from 0.002-0.006 g.
To eliminate the likelihood of addiction and the development of drug dependence, Phenazepam is prescribed in courses whose duration does not exceed 2 weeks. In some cases, the course can be extended up to two months. The drug is discontinued by gradually reducing the dose.
You can buy the drug in pharmacies with a prescription in Latin.
Solution for iv and v / m administration: instructions for use
Phenazepam in the form of a solution is intended for injection into a muscle or vein by a jet or drip method. A single dose of the drug is from 0.0005 to 0.001 g (which corresponds to the contents of half or a whole ampoule). The average daily dose is from 0.0015 to 0.005 g. The maximum dose is considered to be 0.01 g.
Dosage regimen and method of administration of the drug for various diseases:
- Stopping panic attacks, psychotic conditions, fears, increased anxiety, psychomotor agitation: the average daily dose in the initial stages of treatment is from 0.003 to 0.005 g, which corresponds to 3-5 ml of a 0.1% solution. In especially severe cases, the daily dose may be increased to 0.007-0.009 mg.
- Seizures: the drug is administered intramuscularly or intravenously, the initial dose is 0,0005 g.
- Alcohol withdrawal syndrome: the drug is administered intramuscularly or intravenously, the daily dose is from 0.0025 to 0.005 g.
- Neurological diseasesaccompanied by muscle hypertonicity: the drug is recommended to be injected into the muscle at 0.0005 g. Multiplicity of doses is one or two during the day.
- Preliminary medical preparation of patients for surgery and anesthesia: the drug is injected very slowly into a vein at a dose of 0.003 to 0.004 g.
After achieving a positive therapeutic effect after the use of Phenazepam, an intravenous or intramuscular patient is recommended to be transferred with treatment with a drug in the form of a 0.1% solution to an oral dosage form.
The course of treatment with phenazepam injections should not exceed 2 weeks. In some cases, according to the doctor’s testimony, it is extended to 3-4 weeks. When discontinuing the drug, dose reduction should be carried out gradually.
The effects of an overdose of phenazepam
An overdose of phenazepam poses a serious threat to the health and even life of the patient. Therefore, it is very important to monitor the amount of the drug taken. For the same reason, it is not recommended to leave the packaging in places accessible to children.
In cases where the dose is slightly exceeded, the patient develops adverse reactions, mainly aimed at the central nervous system. In addition, the therapeutic effect of Phenazepam may be enhanced.
Significant excess doses are dangerous not only for the nervous system, but also for the heart and respiratory system. This is due to the fact that the drug is characterized by the ability to inhibit the activity of the respiratory center and heart function.
Death from an overdose of phenazepam most often occurs due to cardiac arrest or respiratory arrestTherefore, when the first symptoms of an overdose appear, you should immediately seek medical help.
Self-treatment can only worsen the condition of the patient. The inability to carry out appropriate manipulations without the necessary knowledge will aggravate the situation.
To reduce the toxic effects provoked by Phenazepam, the patient is prescribed drugs characterized by the ability to block benzodiazepine receptors (in particular, Anexatwhich is the specific antidote of Phenazepam).
They are injected into a vein, breeding glucose or isotonic sodium chloride solution in a dose equal to 0.2 mg. In extreme cases, a dose increase of up to 1 mg is allowed.
Also, with an overdose of Phenazepam, the patient requires the appointment of symptomatic therapy aimed at maintaining the function of the heart and lungs. In its absence, there is a high risk that the patient may fall into to whom.
If an overdose provokes undesirable effects from other organs and organ systems, drugs are prescribed that reduce the severity of these phenomena.
Fatal outcome from an overdose of Phenazepam is a fairly common occurrence in alcoholics who combine alcohol with taking the drug. This is due to the ability of Phenazepam to increase the risk of adverse reactions when taking alcohol.
In some cases, doctors have to deal with suicide attempts, when people intentionally drink a large amount of Phenazepam with alcohol.
Concomitant use of phenazepam with drugs that inhibit central nervous system function (including sleeping pills, anticonvulsants and antipsychotic drugs), provokes a mutual strengthening of their action.
Concomitant use with an antiparkinsonian drug Levopodopa reduces the effectiveness of the latter.
Taking Phenazepam with an antiviral agent Zidovudine increases the toxicity of the latter.
Concomitant use with drugs that suppress the processes of microsomal oxidation increases the risk of toxic effects of phenazepam.
Concomitant use with drugs that induce microsomal oxidation processes decreases the therapeutic effectiveness of phenazepam.
Concomitant administration with a tricyclic antidepressant Imipraminehelps to increase the concentration of the latter in blood serum the patient.
The simultaneous administration of antihypertensive drugs increases the severity of antihypertensive effects.
Concomitant administration with antipsychotic Clozapine may increase the effect of respiratory depression.
Terms of sale
You can buy the drug in a pharmacy exclusively by prescription. The prescription of phenazepam is prescribed by your doctor.
Phenazepam is included in list B. It is recommended to store it in a dry place, protected from sunlight and inaccessible to children, at a temperature of no more than 25 ° C.
The drug is allowed to be used within 36 months from the date of manufacture.
Phenazepam analoguesMatches for ATX Level 4 code:SelankTranquesipamMebicarElsepamAdaptolAnvifenAfobazolePhenibutStresamNoofenTenothen
If the drug Phenazepam is not taken correctly (exceeding the recommended doses, treatment for more than two weeks), the patient develops symptoms such as:
- increased drowsiness in the daytime;
- fatigue and a feeling of general weakness;
- decreased attention span;
- decrease in the speed of mental and motor reactions;
- lability of mood;
- negative emotions (unmotivated aggression, irritability, apathy, etc.);
- seizures nausea;
In addition, over time, drug tolerance and dependence develops. Attempts to abandon phenazepam after prolonged use are accompanied by the appearance of pronounced symptoms withdrawal syndrome:
- increased anxiety;
- increased tactile sensitivity;
- increase photosensitivity and sensitivity to sound;
- increased convulsive activity;
In such a situation, most patients taking the drug try to find phenazepam analogues that would provoke fewer side effects.
What can replace phenazepam?
The pharmaceutical market has a fairly large number of drugs that have a similar effect with phenazepam. Among the most famous:
- Nozepam (the active substance is nozepam (oxazepam));
- Medazepam (active substance - medazepam hydrochloride);
- Lorazepam, Ativan, Tavor, Lorenin, Sidenar (the active substance is lorazepam);
- Lorafen (the active substance is lorazepam);
- Alprazolam (the active substance is alprazolam);
- Diazepam, Apaurin, Valium, Seduxen, Relanium, Sibazon, Relium (the active substance is diazepam);
- Grandaxin, Tofisopam (active substance - tofisopam) and others ...
Despite the fact that the names of all these drugs are different, they all belong to the group of anxiolytic drugs and are derivatives benzodiazepine. Accordingly, the negative properties of Phenazepam to one degree or another are inherent in them.
In particular, when taking analogues of the drug may be noted:
- sharp decrease in quantity granulocytes, white blood cells, hemoglobin and platelet count in the blood (below the physiological norm);
- increased salivation, dryness of the oral mucosa, dyspeptic and dyspeptic symptoms;
- impaired functional state of the liver and / or kidneys;
- allergic reactions (skin rash, itching, etc.);
- arterial hypotension.
Like Phenazepam, its analogues are not permitted for the treatment of sleep disorders in patients suffering from nocturnal syndrome apnea. This is due to the ability of benzodiazepine derivatives to have a pronounced muscle relaxant effect.
The drugs relax the muscles and structures of the oropharynx, which in turn can provoke an increase in the frequency of development pharyngeal collapse of the upper respiratory tract and frequencies sleep apnea.
Analogues of the drug also cause various kinds of disturbances in the structure of night sleep (including a change in the ratio of its phases).
Given all of the above complications and potential negative consequences that may develop while taking Phenazepam and drugs similar in its mechanism of action, they can only be used if there are strict indications.
Also, one should not independently seek the answer to the question “How to replace phenazepam?”, Because only the attending physician can correctly choose a replacement for the drug.
Synonyms of Phenazepam
Synonyms of Phenazepam:
Choosing between the preparations “Phenzitat or Phenazepam”, “Phenazepam or Tranquesipam”, it should be remembered that they all contain the same active substance and are characterized by the same spectrum of action.
Phenazepam and alcohol
Every day, hundreds of patients are admitted to hospitals after consuming drugs and alcohol. Doctors often have to deal with cases of phenazepam and alcohol poisoning.
There are several reasons why you can not combine the drug with alcohol. Firstly, their combined use enhances the toxic effects and the likelihood of adverse reactions of the drug. After all, what is phenazepam? This is a tranquilizer, a drug that depresses the central nervous system.
Even a small dose of alcohol taken after a pill or injection of Phenazepam can cause dizziness, increased drowsiness, fear, panic attacks, slow reactions (both mental and motor), loss of clarity of consciousness, the appearance of visions and suicidal tendencies.
Phenazepam sleep with intoxication alcohol significantly increases the likelihood of complications of a drunken sleep, which are expressed as vomiting in the supine position, retrograde amnesia, prolonged compression syndrome (crash syndrome), involuntary emptying of the bladder or intestines.
In addition, the joint use of tablets with alcohol can seriously impair the function of the respiratory center, thereby provoking an attack of suffocation.
If a person does not receive timely qualified assistance, the consequences of such a frivolous attitude to his health can be the most deplorable. There are often situations when doctors are powerless despite all their efforts, and it is not possible to save the patient's life.
Even in cases when help arrives on time and the patient’s life is not in danger, the damage to his health will be very significant. This is due to the fact that co-administration of the drug with alcohol can have the most unpredictable effect on the body.
At least a person exacerbates and complicates the course of existing chronic diseases. Including diseases of the respiratory tract, gastrointestinal tract and liver.
The severity of the effects of phenazepam poisoning in combination with alcohol depends on the individual tolerance of the drug to the individual and the components included in it, as well as the dose of the drug taken. Judging by the reviews left on the forums, for some, phenazepam poisoning with alcohol is expressed in the form of shortness of breath, while others fall into a coma or even die.
Secondly, getting used to Phenazepam is fast enough. Over time, a person develops dependence, which is accompanied by withdrawal symptomsmany times heavier than withdrawal symptoms after alcohol abuse.
It is also important that alcoholics develop dependence on Phenazepam much faster than other categories of patients.
In addition, quite often, when intoxicated, a person loses the ability to control the number of tablets taken, which in turn greatly complicates the severity of alcohol dependence.
Withdrawal syndrome in alcoholics in most cases accompanied by hallucinations, epileptic seizures and depersonalization.
There is an opinion that Phenazepam can be combined with the use of beer, since the latter is almost not even alcohol. However, it is fundamentally wrong.
Despite the fact that drinks made on the basis of hops and malt are classified as light alcohol, their combined use with tranquilizer can cause a typical situation when a person falls into a long-term sound sleep, often accompanied by suffocation.
Awakening occurs, as a rule, not earlier than 12 hours later, and for about another day the body continues to struggle with the symptoms of the aftereffect syndrome: drowsiness, decreased performance, muscle weakness, irritability and depression (sometimes manifested in the most severe form).
Even when drowsiness and asthma attacks are not noted, the effect of beer with Phenazepam is inevitably accompanied by a decrease in the rate of reactions, inhibition of consciousness, increased absent-mindedness and coordination disorders.
So, summarizing the above, we can conclude that the compatibility of phenazepam and alcohol is impossible. In order to avoid the occurrence of health problems, the course of treatment with the drug should be under the strict guidance of a doctor, following all his recommendations.
It is also not recommended to use Phenazepam for a hangover. In combination with the alcohol remaining in the blood after taking alcoholic beverages, the drug can cause the same symptoms as when taken with them (up to death).
Fatal dose for phenazepam and alcohol poisoning
According to doctors, the lethal dose of Phenazepam is a dose exceeding 7-8 ml when the drug is injected into a vein.
Some are interested in the question “How many pills is the lethal dose of phenazepam?" It is well established that a dose exceeding 10 mg of the substance, in combination with alcohol, can lead to death.
If symptoms of the interaction of Phenazepam with alcohol appear, you should immediately contact the Ambulance service for help. Before the arrival of the doctor, it is necessary to constantly monitor the patient's condition, making sure that he does not fall into sleep.
If a person is conscious, it is recommended to rinse his stomach, provoke vomiting, give Activated carbon. Effective may be laxativesthat cope well with the task of removing toxic substances from the body.
In a hospital, infusion therapy is carried out, involving the introduction of ringer's solution, glucose and saline and compliance with the drinking regimen prescribed by the doctor (at least one and a half liters of fluid per day).
If there is a threat of cardiac or respiratory activity, the patient is prescribed the introduction of an antidote (drugs flumazenil) The antidote is administered intravenously or drip in a 5% solution glucose or 9% isotonic sodium chloride solution.
Phenazepam: Prescription or Not?
Phenazepam is a potent drug and, if taken incorrectly, can harm the body. In order to prevent its uncontrolled use, including by adolescents and people who are addicted to alcohol and drugs, he is released exclusively by prescription. Despite this, on the Internet you can often find ads “Buy Phenazepam” or “Sell Phenazepam without a prescription.”
Phenazepam during pregnancy and lactation
During pregnancy and lactation, phenazepam is allowed to be taken only for health reasons.
Taking the drug in the first three months of pregnancy may increase the risk of congenital malformations in the baby.
Its use in the third trimester of pregnancy (and especially in recent weeks) leads to the accumulation of bromodihydrochlorophenylbenzodiazepine in the fetal tissues and, as a consequence, inhibition of the central nervous system in a newborn.
If a woman takes Phenazepam shortly before giving birth, her newborn baby will experience symptoms such as increased muscle weakness, violation of the sucking reflexexpressed hypothermia, respiratory depression.
Long-term use of phenazepam during pregnancy can provoke the development of a child's physical dependence on the drug and symptoms withdrawal syndrome.
With caution, the administration of the drug directly during the period of labor is allowed. For example, when premature birth or if the patient has premature placental abruption.
Introduced parenterally in low doses, Phenazepam, as a rule, does not adversely affect the child. However, the use of high doses of the drug can lead to a violation of the rhythm of heart contractions, lowering blood pressure, asphyxiation, hypothermia etc…
Phenazepam is not recommended for use during lactationbecause bromodihydrochloro phenylbenzodiazepine is able to pass into breast milk. In infants, this substance is metabolized much more slowly than in adults, and its metabolites accumulate in the body, provoking sedative effect.
Because of this, feeding difficulties and losing baby weight are possible.
Reviews of doctors about Phenazepam allow us to conclude that the tool is effective and helps people suffering from sleep problems, ticks, psychotic conditions and alcohol withdrawal.
However, the drug is potent. And for this reason, the course of treatment should be as short as possible. So, the instruction does not recommend taking Phenazepam for longer than two weeks.
The reviews about Phenazepam that people who take the drug leave are quite diverse: someone notes its high effectiveness, and someone is dissatisfied with side effects.
In addition, reviews of Phenazepam on the forums indicate that addiction to the drug develops very quickly. And, despite the fact that it provides the necessary therapeutic effect (facilitating the onset of sleep, for example, or alleviating anxiety), it is more and more difficult to do without it over time.
Many patients note that in the intervals between taking the pills, all negative emotions and unpleasant symptoms worsen, and only the next phenazepam tablet saves the situation.
Phenazepam price where to buy
The price of Phenazepam in the Russian market is:
- 78-100 Russian rubles per pack of 0.0005 mg tablets;
- 89-133 Russian rubles per pack of tablets 0.001 g;
- 132-194 Russian rubles per pack of tablets 0.0025 g;
- 130-198.5 Russian rubles per 10 ampoules of 0.1% solution.
Moreover, the cost of the drug in pharmacies in Moscow and St. Petersburg is slightly higher than in pharmacies of smaller cities.
The price of Phenazepam in Ukraine is from 35.95 UAH. You can find out how much the drug costs on the Internet or if there is no price on the pharmacy’s website by calling the number indicated.
Very often on the forums you can come across questions where to buy Phenazepam without a prescription and how to buy Phenazepam in Moscow if there is no prescription. In this case, most people recommend ordering the drug in an online pharmacy with home delivery.
However, doctors do not recommend buying drugs like Phenazepam online and without a doctor’s prescription.
- Online Pharmacies in Russia
- Online pharmacies in Kazakhstan
- Phenazepam solution in / in and / m 0.1% 1ml n10OAO Novosibkhimpharm147 rub.order
- Phenazepam Tab. dispersion. in the oral cavity 1mg No. 10AO Valenta Pharmaceuticals 137 rub.order
- Phenazepam (amp. 0.1% 1ml №10) 166 rub.order
- Phenazepam (tab. 0,0005g No. 50 blister) 102 rubles to order
- Phenazepam 2.5 mg No. 50 tablets.Valenta Pharmaceuticals OJSC (Russia) 2 tg.order
- Phenazepam 1 mg No. 50 tablets.Valenta Pharmaceuticals OJSC (Russia) 1 tg.order
- Phenazepam 0.5 mg No. 50 tablets.Valenta Pharmaceuticals OJSC (Russia) 1 tg.order